Completed

Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients

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What is being tested

measure Osteocalcin level

Diagnostic Test
Who is being recruted

Stomatognathic Diseases

+ Mouth Diseases

+ Periodontal Diseases

From 25 to 35 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Diagnostic Study

Interventional
Study Start: January 2022
See protocol details

Summary

Principal SponsorFaculty of Dental Medicine for Girls
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 14, 2022

Actual date on which the first participant was enrolled.

This study focuses on understanding how osteocalcin, a protein linked to bone health, changes in a fluid around the gums during dental procedures in people with gum disease. Osteocalcin is present in various body fluids and its levels can hint at how bones are forming and breaking down. This research is important for patients with periodontal (gum) issues who need braces because their bone and gum health impact how teeth move when braces are applied. By investigating the osteocalcin levels, the study aims to improve understanding of bone activity in these patients, which could lead to better dental care and treatment outcomes. Participants in this study will undergo an analysis of the fluid around their gums, known as gingival crevicular fluid, during a specific dental procedure called canine retraction. This procedure is part of the orthodontic treatment where teeth are moved into new positions. Researchers will measure the osteocalcin levels in this fluid. The study does not involve taking medication or undergoing any invasive procedures, but it does involve regular collection of the gum fluid to monitor osteocalcin levels. Monitoring these levels helps in understanding the impact of dental treatments on bone activity, potentially leading to improved orthodontic techniques for those with compromised gum health.

Official TitleOsteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients
Principal SponsorFaculty of Dental Medicine for Girls
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

15 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Diagnostic Study

Diagnostic studies focus on improving how we detect or confirm a disease. They test new tools or techniques that could provide faster or more accurate diagnoses.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 25 to 35 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Stomatognathic DiseasesMouth DiseasesPeriodontal Diseases

Criteria

5 inclusion criteria required to participate
Adult female patients who were seeking for orthodontic treatment with controlled previous chronic periodontitis.

Pocket depth of more than 5 mm before receiving non-surgical periodontal treatment or/and Pocket depth of less than 4 mm after periodontal therapy.

Sever to very sever irregularity of mandibular anterior arch according to Little's irregularity index ranging from 7 to 10 mm with acceptable oral hygiene.

all the permanent dentition excluding third molars should be present.

Show More Criteria

3 exclusion criteria prevent from participating
Previous orthodontic treatment.

Patients with aggressive periodontitis or Any smoking habits.

Pregnant or lactating female patients were excluded.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
periodontal compromised adults female patients with sever dental crowding and seeking for orthodontic treatment

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

faculty of dental medicine Azhar University

Cairo, EgyptOpen faculty of dental medicine Azhar University in Google Maps
CompletedOne Study Center