Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy: A Randomized Controlled Trial

This clinical trial focuses on finding the best way to treat chemotherapy-induced neuropathy, a common side effect that causes pain and discomfort in cancer patients undergoing chemotherapy. The study compares the effects of using the medication Duloxetine alone versus combining it with either Gabapentin or Amitriptyline. The goal is to determine which combination can most effectively relieve the symptoms of neuropathy while also being safe for patients. This research is important because it could lead to better pain management options for those dealing with the challenging side effects of cancer treatment. Participants in the study are divided into groups and given different treatments. One group receives Duloxetine alone, while the other groups receive Duloxetine combined with either Gabapentin or Amitriptyline. The medications are taken as prescribed by the healthcare provider, and their effects on neuropathy symptoms are closely monitored. The study evaluates how well each treatment eases the symptoms and checks for any side effects, aiming to identify the most effective and safest approach for managing chemotherapy-induced neuropathy.