Completed

Effects of Chia Seed Consumption in Comparison With Marine Omega-3 Supplementation on the Concentration of Blood Lipid and Inflammatory Factors in Hypertriglyceridemic Patients

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What is being tested

Control

+ Omega-3 supplementation

+ Chia seed

OtherDietary Supplement
Who is being recruted

Hyperlipidemias+3

+ Metabolic Diseases

+ Nutritional and Metabolic Diseases

From 18 to 70 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Placebo-Controlled
Interventional
Study Start: September 2023
See protocol details

Summary

Principal SponsorShahid Beheshti University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 18, 2023

Actual date on which the first participant was enrolled.

This clinical trial investigates the effects of consuming chia seeds compared to marine omega-3 supplements on people with mild to moderate high triglycerides, a condition known as hypertriglyceridemia. Individuals with specific health conditions like severe kidney disease, AIDS, cancer under treatment, liver cirrhosis, and those using certain medications or supplements are not eligible to participate. The study aims to explore new dietary approaches to manage triglyceride levels and inflammation, potentially offering alternative options to improve heart health and reduce the risk of related complications. Participants in this study are divided into three groups for eight weeks. One group receives placebo capsules containing sunflower oil, another takes omega-3 capsules, and the third consumes chia seeds. All participants follow a low-calorie diet during the trial. Researchers assess changes by measuring body weight, blood pressure, and blood levels of lipids, lipoproteins, and inflammation markers at the start and end of the study. This helps determine the effectiveness of chia seeds and omega-3 supplements in managing blood triglycerides and inflammation.

Official TitleEffects of Chia Seed Consumption in Comparison With Marine Omega-3 Supplementation on the Concentration of Blood Lipid and Inflammatory Factors in Hypertriglyceridemic Patients
NCT06020950
Principal SponsorShahid Beheshti University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

66 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

HyperlipidemiasMetabolic DiseasesNutritional and Metabolic DiseasesHypertriglyceridemiaDyslipidemiasLipid Metabolism Disorders

Criteria

1 inclusion criteria required to participate
Individuals who had fasting triglyceride concentration 150-499 mg/dL in their two previous tests

9 exclusion criteria prevent from participating
Being treated with fibrate medications

Being treated glucocorticoids

Being treated with anticoagulants (except aspirin)

Continuous use of omega-3 supplements or in the past month

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

33.333% chance of being blinded to the placebo group

Treatment Groups

Group I

Placebo
Reduced calorie diet along with placebo (sunflower oil) pearls

Group II

Active Comparator
Reduced calorie diet along with omega-3 supplementation

Group III

Experimental
Reduced calorie diet along with chia seed consumption

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Clinical Nutrition Research Unit, National Nutrition and Food Technology Research Institute

Tehran, IranOpen Clinical Nutrition Research Unit, National Nutrition and Food Technology Research Institute in Google Maps
CompletedOne Study Center