Recruiting

BreatheSBreathing Rescue for SUDEP Prevention (BreatheS)

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What is being tested

Breathing tasks

+ Brain mapping with stimulation

OtherDevice
Who is being recruted

Brain Diseases+2

+ Central Nervous System Diseases

+ Epilepsy

Over 18 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: July 2023
See protocol details

Summary

Principal SponsorThe University of Texas Health Science Center, Houston
Study ContactNuria L Lecumberri, MD,PhDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 31, 2023

Actual date on which the first participant was enrolled.

This study aims to understand how certain networks in the human brain control breathing, especially in situations where seizures might disrupt normal breathing. The focus is on identifying specific areas in the brain and techniques that can help prevent breathing problems caused by seizures. This research is particularly important for individuals who are at risk of SUDEP, which stands for Sudden Unexpected Death in Epilepsy. By finding ways to prevent seizure-related breathing issues, this study hopes to reduce the risk of SUDEP and improve safety for people with epilepsy. Participants in this study will undergo activities and tests that help researchers map out brain networks related to breathing. The study does not involve new medications but instead focuses on understanding brain functions and how they can be influenced to maintain normal breathing during seizures. Researchers will use non-invasive techniques to monitor brain activity and responses, ensuring the safety and comfort of participants while gathering crucial data. The findings will contribute to better prevention strategies for breathing failures during seizures.

Official TitleBreathing Rescue for SUDEP Prevention (BreatheS)
NCT05981755
Principal SponsorThe University of Texas Health Science Center, Houston
Study ContactNuria L Lecumberri, MD,PhDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

100 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain DiseasesCentral Nervous System DiseasesEpilepsyEpilepsies, PartialNervous System Diseases

Criteria

2 inclusion criteria required to participate
diagnosis of intractable focal epilepsy

admitted to the Epilepsy Monitoring Unit (EMU) at Memorial Hermann-Texas Medical Center for intracranial subdural strips, grids, or depth electrode placement study (invasive video-EEG)

3 exclusion criteria prevent from participating
respiratory, cardiac or cerebrovascular disease

pregnancy

prisoners

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

The University of Texas Health Science Center at Houston

Houston, United StatesOpen The University of Texas Health Science Center at Houston in Google Maps
Recruiting
One Study Center