Completed

Effect of Soft Tissue Volume on Midfacial Gingival Margin Alterations Following Immediate Implant Placement in the Esthetic Zone: A 1-Year Randomized Clinical and Volumetric Trial

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What is being tested

Connective tissue graft /Bone graft/ Customized HA

Procedure
Who is being recruted

From 18 to 50 Years
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: January 2022
See protocol details

Summary

Principal SponsorCairo University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 13, 2022

Actual date on which the first participant was enrolled.

The study focuses on improving the appearance and stability of the gums after a tooth is extracted and an implant is placed. When a tooth is removed, the surrounding gum and bone can change shape, causing the gum line to recede. This research aims to find out if using special devices called customized contoured healing abutments, along with or without connective tissue grafts, can better maintain the original appearance and shape of the gums. This is important because it seeks to provide a solution that not only enhances the look but also ensures the long-term stability of the gums and surrounding tissues, especially in visible areas of the mouth. Participants in the study receive immediate implants after tooth extraction in the front part of the mouth, known as the esthetic zone. They are then treated with either a customized healing abutment or a combination of the abutment and connective tissue graft. The study observes how well these methods maintain the gum's shape and position over a year. The results are evaluated by looking at the gum line changes and overall tissue stability, helping determine the most effective technique for preserving the natural appearance of gums after dental implants.

Official TitleEffect of Soft Tissue Volume on Midfacial Gingival Margin Alterations Following Immediate Implant Placement in the Esthetic Zone: A 1-Year Randomized Clinical and Volumetric Trial
NCT05975515
Principal SponsorCairo University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

39 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

Inclusion Criteria: * Patient-related criteria: * Adults at or above the age of 18. * Non-restorable maxillary anterior or premolar tooth requiring extraction and needed an implant placing therapy. * The failing tooth will have adjacent and opposing natural teeth. * Sufficient mesial-distal and interocclusal space for placement of the implant and definitive restoration. * Able to tolerate surgical periodontal procedures. * Good oral hygiene. * Compliance with the maintenance program. * Provide informed consent. * Accepts the one-year follow-up period. Teeth related criteria: * Intact thick biotype gingival tissue with at least 2mm band of keratinized tissue. * Intact socket wall before the extraction, buccal bone thickness ≤1mm assessed by CBCT. * Sufficient apical bone to place an immediate implant with minimum primary stability of 30Ncm Exclusion Criteria: * Patients diagnosed with periodontal diseases. * Current or previous smokers. * Pregnant and lactating females. * Patients with medical conditions that would compromise the surgical procedures; uncontrolled diabetes mellitus, taking IV Bis-phosphonates for treatment of osteoporosis. * Patients with active infection related at the site of implant/bone graft placement. * Patients with parafunctional habits

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Group 3 (intervention 2 group): immediate implant placement with customized healing abutment

Group II

Active Comparator
Group1 (control group): immediate implant placement with bone grafts till crest and customized healing abutment.

Group III

Experimental
Group 2 (intervention 1 group): Immediate implant placement with CTG and customized healing abutment.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

IDCE

Cairo, EgyptOpen IDCE in Google Maps
CompletedOne Study Center