Completed

Green Dialysis: Hemodialysis With Reduced Dialysate Flow

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What is being tested

Blood and dialysate sampling

Other
Who is being recruted

Over 18 Years
+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2023
See protocol details

Summary

Principal SponsorUniversity Hospital, Ghent
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 18, 2023

Actual date on which the first participant was enrolled.

This study explores a new approach to hemodialysis, which is a treatment used to clean the blood in patients with kidney failure. The current methods use a lot of water, which can be concerning from an environmental standpoint. This research aims to determine if using less water during hemodialysis, by reducing the flow of dialysate, can still effectively remove waste toxins from the blood. Specifically, it looks at comparing the effectiveness of different types of membranes used in the process to see if smaller, more open fibers in the dialyzer might be more efficient. Participants in this study will undergo hemodialysis using either a standard high-flux dialyzer or a medium cut-off membrane with varying dialysate flows. The process will measure how well these methods remove certain toxins that build up in the blood due to kidney failure. While the study does not mention specific risks or benefits, the goal is to find a method that minimizes water use without compromising the treatment's effectiveness. By focusing on different dialyzer types and flow rates, the study aims to improve the sustainability of hemodialysis treatments.

Official TitleGreen Dialysis: Hemodialysis With Reduced Dialysate Flow
NCT05974436
Principal SponsorUniversity Hospital, Ghent
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

10 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

2 inclusion criteria required to participate
stable chronic hemodialysis patient

well functioning vascular access

2 exclusion criteria prevent from participating
active infection

malignancies

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Patients are dialysed at midweek using hemodiafiltration (autoflow) with an FX800 Cordiax high-flux dialyzer, with dialysate flow of 700mL/min

Group II

Experimental
Patients are dialysed at midweek using hemodialysis with a Theranova 400 medium cut-off dialyzer with dialysate flow of 700mL/min

Group III

Experimental
Patients are dialysed at midweek using hemodialysis with a Theranova 400 medium cut-off dialyzer with dialysate flow of 300mL/min

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Ghent University Hospital

Ghent, BelgiumOpen Ghent University Hospital in Google Maps
CompletedOne Study Center