Suspended

MEESSIMEESSI-AHF Scale Impact on Acute Heart Failure Patient Prognosis and Decision Making

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Study Aim

This study aims to evaluate the impact of the MEESSI-AHF Scale on the prognosis and decision-making for patients with acute heart failure, by measuring the number of days alive and out of hospital, and the rate of all-cause death within 30 days of randomization.

What is being tested

Risk stratification before decision-making about patient hospitalization or discharge

Procedure
Who is being recruted

Emergencies+1

+ Pathologic Processes

+ Pathological Conditions, Signs and Symptoms

+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: June 2023
See protocol details

Summary

Principal SponsorHospital Clinic of Barcelona
Study ContactOscar Miro, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 27, 2023

Actual date on which the first participant was enrolled.

This study focuses on evaluating the impact of the MEESSI-AHF scale, a tool designed to assess the risk in patients diagnosed with Acute Heart Failure (AHF) in emergency departments. The study involves over 8,000 patients across 16 Spanish emergency departments. The main goal is to understand how using this scale can influence decision-making and the overall prognosis of AHF patients. This research is crucial as it could potentially improve the care and outcomes for patients with Acute Heart Failure. The study consists of three parts. In the first part, patients receive usual care and their risk is retrospectively stratified using the MEESSI-AHF scale. The second part involves a quasi-experimental approach where some patients receive usual care, while others have their risk assessed using the MEESSI-AHF scale before a decision is made. The third part is a randomized clinical trial where patients are either managed with usual care or with the use of the MEESSI-AHF scale. The primary outcomes measured include death from any cause and cardiovascular cause at 30 days and 1 year, combined events (revisit to the ED or hospitalization for AHF or death) at 30 days post-discharge, days alive and outside the hospital at 30 days after the initial ED visit, and the proportion of patients managed without hospitalization.

Official TitleEvaluation of the Impact of the MEESSI-AHF Scale on Decision Making and the Prognosis of Patients Diagnosed With Acute Heart Failure in the Emergency
NCT05919225
Principal SponsorHospital Clinic of Barcelona
Study ContactOscar Miro, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

3200 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

EmergenciesPathologic ProcessesPathological Conditions, Signs and SymptomsDisease Attributes

Criteria

3 inclusion criteria required to participate
Clinical diagnosis of AHF based on Framinham criteria

NT-proBNP >300 pg/mL

Patient able to consent

1 exclusion criteria prevent from participating
ST-elevation acute coronary syndrome

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Once AHF has been diagnosed at ED, and before decision-making about hospitalize/discharge home is taken, physicians will objectively measure the severity of decompensation, based on risk of 30-day death using MEESSI scale. As result, patient can be allocated to low, intermediate, high or very-high risk. For patients classified as low-risk, the propocol recommendation will be discharge patient to home. For patients classified as increased risk (i.e., intermediate, high or very-high risk categories), the protocol recommendation will be to hospitalize patient. Nonetheless, final decission will be left to emergency physician, and overruling (disposition against recommendation) will be allowed. For discharged patients, there is no follow up intervention planned, and it will be based on current centre protocols.For hospitalized patients, department of admission will be based on current centre protocols, with no intervention at this level.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 19 locations

Recruiting

Emergency Department, Hospital de Bellvitge

L'Hospitalet de Llobregat, SpainOpen Emergency Department, Hospital de Bellvitge in Google Maps
Recruiting

Emergency department

Barcelona, Spain
Recruiting

Emergency Department, Hospital de Getafe

Getafe, Spain
Recruiting

Emergency Department, Hospital de Móstoles

Móstoles, Spain
Suspended19 Study Centers