Completed

Paternal ClockThe Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation

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What is being collected

Data Collection

Collected from past medical records and data - Retrospective
Who is being recruted

Urogenital Diseases+3

+ Genital Diseases

+ Genital Diseases, Male

Over 18 Years
1 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: June 2023
See protocol details

Summary

Principal SponsorClinique Ovo
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 10, 2023

Actual date on which the first participant was enrolled.

Sperm DNA fragmentation (SDF) serves as a marker for chromatin and DNA damage in sperm. Assessing sperm DNA integrity is crucial in male fertility evaluation since high levels of SDF are associated with a greater number of adverse reproductive outcomes, including an increased risk of miscarriage and birth defects. Recent research suggests that advanced paternal age (APA) may lead to DNA damage in sperm, however the precise age at which this risk becomes apparent has not yet been clearly defined, necessitating the identification of the point in time at which high SDF levels occur. With the help of this knowledge, male infertility can be diagnosed with greater accuracy, and infertile couples can receive appropriate care.

Official TitleThe Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation
NCT05894356
Principal SponsorClinique Ovo
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

4250 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesGenital DiseasesGenital Diseases, MaleInfertilityInfertility, MaleMale Urogenital Diseases

Criteria

1 inclusion criteria required to participate
Male of at least 18 years of age

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Clinique Ovo

Montreal, CanadaOpen Clinique Ovo in Google Maps
CompletedOne Study Center