Recruiting

BASAAspirin 81 mg vs 325 mg for Stroke Prevention in Head and Neck Vessels Injury

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Study Aim

This study aims to compare the effectiveness of Aspirin 81 mg and 325 mg in preventing new stroke events (ischemic or hemorrhagic) in individuals with head and neck vessel injuries.

What is being tested

Aspirin 325Mg Tab, Aspirin 81Mg Tab

Drug
Who is being recruted

Over 18 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Phase 4
Interventional
Study Start: August 2023
See protocol details

Summary

Principal SponsorLoma Linda University
Study ContactMaryam B Tabrizi, M.DMore contacts
Last updated: January 31, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 23, 2023

Actual date on which the first participant was enrolled.

This clinical trial focuses on comparing the effectiveness of two different doses of Aspirin, 81 mg and 325 mg, in preventing strokes. The study involves patients who have experienced an injury to the blood vessels in their head and neck area. The main aim is to understand if the lower dose of Aspirin, 81 mg, is as effective as the higher dose, 325 mg, in stroke prevention. Additionally, the study also seeks to determine if the rate of bleeding complications is not higher in patients taking the lower dose. This research is important as it can help improve the care and treatment strategies for patients with such injuries. During the trial, participants are randomly assigned to take either Aspirin 81 mg or Aspirin 325 mg. The primary outcome being measured is the number of patients who experience a new stroke event, which could be either an ischemic stroke (caused by blood clots) or a hemorrhagic stroke (caused by bleeding in the brain). The study is designed to evaluate how well each dose of Aspirin prevents these events while also monitoring for any potential side effects or complications.

Official TitlePilot, Non-masked, Randomized Clinical Trial for Evaluation of Stroke Rate in Patients With Blunt Cerebrovascular Injury (BCVI) Treated With Oral Acetylsalicylic Acid (ASA) 81 mg Versus ASA 325 mg (BASA).
Principal SponsorLoma Linda University
Study ContactMaryam B Tabrizi, M.DMore contacts
Last updated: January 31, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

98 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

2 inclusion criteria required to participate
Age ≥18

All patients with blunt cerebrovascular injury are diagnosed by computed tomography angiography (CTA) upon admission

9 exclusion criteria prevent from participating
Age <18

Pregnant women

No enteral route access for Aspirin administration

Patients who are on Heparin drip or other full dose anticoagulation when BCVI diagnosed

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator

Group II

Active Comparator

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Loma Linda University Medical Center

Loma Linda, United StatesOpen Loma Linda University Medical Center in Google Maps
Recruiting
One Study Center