Collagen Peptide Supplementation for Wound Healing After Knee Replacement Surgery
This study aims to evaluate whether taking collagen peptide supplements before knee replacement surgery affects mRNA levels in the anterior cruciate ligament.
SOLUGEL
+ Placebo
Arthritis+3
+ Joint Diseases
+ Musculoskeletal Diseases
Treatment Study
Summary
Study start date: February 1, 2026
Actual date on which the first participant was enrolled.This study aims to investigate whether taking collagen peptide supplements can help with tissue healing, functional outcomes, and wound healing for people undergoing total knee replacement surgery. The focus is on individuals who are planning to have this surgery, as the researchers want to see if these supplements can improve recovery and overall outcomes. This is important because knee replacement surgery can have a significant impact on daily life, and finding ways to enhance recovery could greatly benefit those undergoing the procedure. During the study, participants will either take a collagen peptide supplement or a placebo over 24 weeks. Before and after surgery, various tests and assessments will be done, including checking knee function, mood, physical activity, and pain levels. Blood and tissue samples will be collected during surgery to monitor changes at a molecular level. Physical therapy is also part of the recovery process. The results are measured through a series of physical and functional tests, ensuring a comprehensive look at how the supplements might aid recovery. Participants will have both in-person and virtual check-ins to monitor progress and adherence to the study plan.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.44 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 50 to 75 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Males and Females, 50 to 75 years old * With a body mass index of 20.0 to 39.9 kg/m2 * Diagnosed with primary osteoarthritis * Scheduled for a TKA at UAMS (two months prior to surgery) at UAMS * Live near Little Rock and scheduled to attend physical therapy in Little Rock * COVID-19 negative and/or asymptomatic. Exclusion Criteria: * Previously sustained serious knee injury or surgery to ACL in TKA knee * Females not postmenopausal * Having undergone hormone replacement therapy in the last 12 months. * Active diagnosis of blood borne infectious disease
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
50% chance of being blinded to the placebo group
Treatment Groups
Group I
ExperimentalGroup II
PlaceboStudy Objectives
Primary Objectives