Effect of Oral L-Citrulline on Peripheral and Central Endothelial Function in Young and Older Adults

This study explores how a substance called L-Citrulline affects blood vessel function in both young and older adults. L-Citrulline is a compound that our bodies can convert into another substance called nitric oxide (NO), which is crucial for regulating blood pressure and blood flow, and maintaining overall vascular health. As we age, our bodies tend to produce less nitric oxide, especially if we're not very active. While L-Citrulline's effects on muscle strength, endurance, and blood vessel function in various health conditions are well-studied, its impact on brain blood vessels is not well understood. During this study, participants will take L-Citrulline orally. Researchers will then measure changes in brain activity and blood flow using techniques like EEG, functional near-infrared spectroscopy (fNIRS), and dynamic retinal vessel analysis. These measurements will be taken before and after treatment to see if L-Citrulline makes a difference. Results will be reported as a percentage change from the starting point. The potential risks and benefits of L-Citrulline on brain blood vessel function could provide valuable insights into how we can maintain vascular health as we age.