Completed

MARRSMillipede System for Acute Ischemic Stroke due to LVOs

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What is being tested

Millipede System

Device
Who is being recruted

Ischemic Stroke+5

+ Brain Diseases

+ Cardiovascular Diseases

From 18 to 85 Years
+44 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: October 2023
See protocol details

Summary

Principal SponsorPerfuze
Last updated: March 12, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 9, 2023

Actual date on which the first participant was enrolled.

Stroke is a serious condition that affects around 795,000 people in the United States every year. The Millipede AspiRation for Revascularization in Stroke (MARRS) study is looking into a new treatment method for acute ischemic stroke, which happens due to large vessel blockages. This study is particularly important as it aims to evaluate the safety and effectiveness of the Millipede System, a device designed to help stroke patients. During the study, participants will undergo a procedure using the Millipede System. The main goal is to achieve successful blood flow restoration in the brain, measured by a score known as mTICI. This score indicates how well the blood is flowing after the procedure. The study will also monitor all adverse events to determine the safety of the Millipede System, paying special attention to any brain bleeding and other complications that could lead to worsening neurological conditions or death.

Official TitleMillipede AspiRation for Revascularization in Stroke (MARRS) Study
NCT05714501
Principal SponsorPerfuze
Last updated: March 12, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

246 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 85 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Ischemic StrokeBrain DiseasesCardiovascular DiseasesCentral Nervous System DiseasesCerebrovascular DisordersNervous System DiseasesVascular DiseasesStroke

Criteria

11 inclusion criteria required to participate
Subjects aged ≥ 18 and ≤ 85 years.
Pre-stroke mRS score of ≤ 1.
Baseline NIHSS score of ≥ 6.
A new focal disabling neurologic deficit consistent with acute cerebral ischemia.
Show More Criteria
33 exclusion criteria prevent from participating
Known aneurysm at or near the target treatment segment.
Known previous stroke within the past 3 months.
Females who are known to be pregnant or breastfeeding.
In the Investigator's opinion, any known comorbidity (including COVID-19) that may complicate treatment or prevent improvement or follow-up.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Millipede System

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 23 locations

Suspended

Yale University Hospital

New Haven, United StatesOpen Yale University Hospital in Google Maps
Suspended

Baptist Health Research Institute

Jacksonville, United States
Suspended

Tampa General Hosital

Tampa, United States
Suspended

Emory

Atlanta, United States
Completed23 Study Centers
MARRS | Millipede System for Acute Ischemic Stroke due to LVOs | PatLynk