Suspended

Comparison of Bio-PRF and Alveogyl in Alveolar Osteitis Treatment

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Bio-PRF

+ Alveogyl

BiologicalDrug
Who is being recruted

Dry Socket+4

+ Stomatognathic Diseases

+ Mouth Diseases

Over 18 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: October 2022
See protocol details

Summary

Principal SponsorUniversity of Dublin, Trinity College
Study ContactMaeve Cooney
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 1, 2022

Actual date on which the first participant was enrolled.

Alveolar osteitis, also known as dry socket, is a painful condition that can occur after a tooth extraction. It's characterized by increased pain around the extraction site within one to three days post-procedure, often accompanied by loss of the blood clot from the socket. This study focuses on comparing two treatments for dry socket: an experimental treatment called Bio-PRF and a commonly used treatment, Alveogyl. The goal is to improve care for those who experience this complication, which can affect up to 30% of people after third molar extractions. Participants in this study will be randomly assigned to receive either Bio-PRF or Alveogyl after a tooth extraction. The study will measure changes in pain levels using a pain diary with a scale from 0-100. These measurements will be taken at baseline, day 3, and day 7. By comparing these results, the study aims to understand the effectiveness of these treatments in managing pain associated with dry socket.

Official TitleA Clinical Investigation of the Efficacy of Platelet Rich Fibrin (Bio-PRF) Compared to Alveogyl in the Treatment of Alveolar Osteitis
NCT05615272
Principal SponsorUniversity of Dublin, Trinity College
Study ContactMaeve Cooney
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

58 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dry SocketStomatognathic DiseasesMouth DiseasesNeurologic ManifestationsPainSigns and SymptomsPathological Conditions, Signs and Symptoms

Criteria

4 inclusion criteria required to participate
Male and females adults at least 18 years old
A diagnosis of alveolar osteitis following tooth extraction based on patients having both pain and exposed bone
Good command of the English language
Willingness to keep a diary of symptoms and travel for the review appointment on day 7 following intervention
4 exclusion criteria prevent from participating
Pregnant or breastfeeding women
Current or previous bisphosphonate used or history of radiotherapy to the jaws
Allergy or intolerance to study materials
Lack of capacity to consent to participate in the study

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
This is a blood-derived platelet rich concentrate from the patient's whole blood sample. The patient typically donates two 9ml (1.5 tablespoons) vials of blood that is then spun in a centrifuge.

Group II

Active Comparator
Alveogyl is an intraalveolar sedative, obtundent dressing, which contains the active ingredient eugenol.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Dublin Dental University Hospital

Dublin, IrelandOpen Dublin Dental University Hospital in Google Maps
SuspendedOne Study Center