VULNERABLEVulnerable Plaque Treatment in Multivessel STEMI Patients

This study focuses on patients who have experienced a specific type of heart attack known as ST-elevation myocardial infarction (STEMI) and have blockages in multiple heart vessels. The goal is to determine if certain types of plaques in the heart vessels, identified as vulnerable through a special imaging test, should be treated with a stent in addition to standard medication. This is important because identifying and treating these plaques could potentially prevent further heart issues, such as heart attacks or the need for additional heart procedures, thereby improving patient outcomes. Participants in the study undergo a series of evaluations to determine the best course of treatment. Initially, a test called fractional flow reserve (FFR) measures how well blood flows through the narrowed sections of the heart vessels. If the flow is too low, a procedure called percutaneous coronary intervention (PCI) is performed. If the flow is adequate, further imaging with optical coherence tomography (OCT) checks for vulnerable plaques. Participants with these plaques are either treated with PCI and medication or just medication, to compare which approach is more effective. The study measures outcomes such as heart-related deaths, heart attacks related to the treated vessels, and the need for additional procedures on the same vessels.