Completed

Broccoli Sprouts-enriched Diet for Ulcerative Colitis Management

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What is being tested

1 Serving of broccoli sprouts

+ 3 Servings of broccoli sprouts

Dietary Supplement
Who is being recruted

Colitis+5

+ Colitis, Ulcerative

+ Colonic Diseases

Over 18 Years
+12 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: May 2023
See protocol details

Summary

Principal SponsorUniversity of Michigan
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 23, 2023

Actual date on which the first participant was enrolled.

This study aims to help people with mild ulcerative colitis, a condition that causes inflammation in the digestive tract. The researchers want to find out if eating a certain amount of broccoli sprouts can increase a substance called sulforaphane in the body and reduce inflammation. This could potentially lead to a new way of managing ulcerative colitis, especially for those who struggle with current treatments. The study is small and is meant to prepare for a larger one in the future. Participants in this study will be asked to follow a diet that includes steamed broccoli sprouts. The researchers will measure how well participants stick to this diet and how difficult they find it to eat broccoli sprouts. They will also measure the levels of sulforaphane in the blood and stool. The study will use self-reported data and questionnaires to gather this information. The potential benefit of this study is that it may lead to a dietary approach to managing ulcerative colitis.

Official TitleA Pilot Feasibility Study to Develop a Broccoli Sprouts-enriched Diet in the Management of Ulcerative Colitis
NCT05507931
Principal SponsorUniversity of Michigan
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

23 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

ColitisColitis, UlcerativeColonic DiseasesDigestive System DiseasesGastroenteritisGastrointestinal DiseasesIntestinal DiseasesInflammatory Bowel Diseases

Criteria

8 inclusion criteria required to participate
If on steroids, prednisone dose not more than 20 mg daily and entocort not more than 9 mg daily, with no dose changes within 2 weeks before the Day 0 visit

All other medications require a stable dose for at least 8 weeks prior to enrollment.

No dose changes to any IBD medication anticipated for the duration of the study

Body Mass Index (BMI) values 18.5-40 kg/m2

Show More Criteria

4 exclusion criteria prevent from participating
Taking Non-steroidal anti-inflammatory drugs (NSAIDs)

Newly diagnosed (within past month), or uncontrolled diabetes or cardiovascular disease

Consumption of more than 5 ½ cups of servings/day of fruits and vegetables as assessed by the National Cancer Institute (NCI) Diet History Questionaire III online Food Questionnaire.

A known allergy or sensitivity to cruciferous vegetables like arugula, bok choy, broccoli, cabbage, cauliflower, or collard greens

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
113 grams

Group II

Experimental
339 grams

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Michigan

Ann Arbor, United StatesOpen University of Michigan in Google Maps
CompletedOne Study Center