Safety and Effectiveness of VL-PX10 + VL-P22 Treatment on Pulmonary Fibrosis Secondary to Covid-19
VL-PX10 and VL-P22 plus standard care
+ Placebo
Fibrosis+4
+ Lung Diseases
+ Pathologic Processes
Treatment Study
Summary
Study start date: November 30, 2022
Actual date on which the first participant was enrolled.Multiple clinical trials are underway to explore options for treatment of pulmonary fibrosis in patients with history of COVID. Mesenchymal stem cell (MSC)-based therapies have been used worldwide for various pulmonary diseases. A recent review of over 110 reports of clinical trials worldwide with MSC-based therapies in pulmonary diseases found that these therapies have been reported to be safe and effective in the treatment of acute/viral pulmonary disease, community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia (BPD), interstitial lung diseases (ILD), chronic pulmonary fibrosis, bronchiolitis obliterans syndrome (BOS) and lung cancer. A phase 2 clinical trial in 101 severe Covid-19 patients with lung damage using human umbilical cord derived MSCs found that the treatment exerted numerical improvement in whole lung lesion volume and the 6-minute walk test from baseline to day 28 compared with the placebo. This proof of concept, double-blind, placebo-controlled trial will evaluate the safety and efficacy of intravenous infusion of VL-PX10 and VL-P22, versus placebo, for use in the treatment of Covid induced Pulmonary Fibrosis. This is an add-on treatment study; subjects will be allowed to take standard of care treatments available. The study will have two arms (n=10 each): 1. Experimental/treatment arm: VL-PX10 and VL-P22 plus standard care 2. Placebo: Saline plus standard care The study duration would be 5 days of treatment plus 12 weeks follow up.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.20 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 25 to 90 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Subjects will be eligible for enrollment in the study only if they meet the following criteria: 1. Male or female, aged between 25 years (including) to 90 years old 2. Confirmed and documented COVID-19 infection history with confirmed diagnosis of Pulmonary Fibrosis 3. Negative to current Covid-19 infection as tested by RT-PCR/rapid antigen tests 4. Able to perform a 6-minute walk test 5. Blood routine, liver and kidney functions test values are within controllable range 1. Adequate hepatic function as evidenced by ALT and AST \< 2X ULN and bilirubin \< 1.5X ULN for the reference lab 2. Adequate renal function as evidenced by a serum creatinine ≤ 1.5 X ULN for the reference laboratory OR a calculated creatinine clearance of ≥ 60 mL/min by the Cockcroft-Gault Equation 3. Adequate hematopoietic function as evidenced by white blood cells ≥ 3x109 / L and platelets ≥ 100x109 / L 6. If childbearing age: agree to practice effective birth control from screening until 12 weeks after the last study treatment. Exclusion Criteria: * Subjects will be ineligible for enrollment in the study if they meet any of the following criteria: 1. Clinically relevant heart condition such as, but not limited to, uncontrolled heart failure, severe pulmonary hypertension, atrial fibrillation or significant congenital heart disease 2. Severe asthma on chronic therapy with biologics or steroids 3. Active smokers as defined as individuals who currently smokes at least one cigarette or equivalent product a day. (Ex-smokers who had regularly smoked but who had not smoked the previous month are eligible) 4. Evidence of active malignancy, or prior history of active malignancy not in remission. 5. Life expectancy of \< 6 months 6. Patient included in another ongoing interventional therapeutic trial. 7. Pregnant or Lactating. 8. Serious or life-threatening co-morbidities, that in the opinion of the investigators, may compromise the safety or compliance with the study guidelines and tracking.
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
50% chance of being blinded to the placebo group
Treatment Groups
Group I
ExperimentalGroup II
PlaceboStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location