An Open-Label, Randomized, Fasting Condition, Single-dose, Cross-over Study to Evaluate the Bioequivalence "DA-5215 Tab" and "DA-5215-R Tab" in Healthy Volunteers
DA-5215 Tab
+ DA-5215-R Tab
Treatment Study
Summary
Study start date: May 1, 2022
Actual date on which the first participant was enrolled.1. Study design: An open-Label, randomized, 2-sequence, 2-period, fasting condition, single-dose, per oral, cross-over study 2. Administration method: The subject should maintain a minimum of 10 hours of fasting status before administration, and give an oral dose of 1 tablet (DA-5215 or DA-5215-R) with 150 mL of water at around 8 a.m. on 1D of each period. The subject should not chew or break the drug, but should swallow in whole with water. The difference in administration time between the subjects is about one minute apart, considering the blood collection time. 3. Wash out period: at least 7 days 4. Blood collection time: Before the administration,15, 30, 45 min, 1, 1.5, 2, 2.5, 3, 3.5, 4, 6, 8, 12, 24, 48 hours after the administration (total 16 times)
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.50 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 19 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Criteria
Inclusion Criteria: 1. A person who aged 19 or older at the time of screening 2. BMI of 18 to 30 (BMI calculation: kg/m2) \- Males weighing 50kg or more, Females weighing 45kg or more 3. No congenital or chronic diseases or pathological symptoms 4. A person who is judged to be suitable for the study by the investigator based on the clinical laboratory examination 5. A person who agreed to use contraception from the first administration of IP to a week after the last administration of IP 6. A person who has fully understood the contents of the consent form for the study and signed the consent form voluntarily and recorded the date of signature Exclusion Criteria: 1. A person who has taken a drug that significantly induces (e.g., barbital) or inhibits the drug metabolic enzyme within 30 days prior to the first administration of IP 2. A person who has participated in other clinical trials within six months prior to the first administration of the IP 3. A person who has had whole blood transfusion within 8 weeks or the apheresis within 2 weeks before the first administration of IP 4. A person who has medical history of gastric resection that can affect the drug absorption 5. A person with a history of regular alcohol intake within a month prior to the first administration of the IP: * Male: More than 21 cups/week * Female: More than 14 cups/week (1 cup: 50 ml of soju, 250 ml of beer, 30ml of spirits) 6. A person who is hypersensitive to any of the IP components 7. A person who has medical history of mental disease 8. A person who is judged not to be suitable for the study by the investigator 9. Lactating or possibly pregnant women
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location