Suspended

A Phase I Trial of Activated Autologous T Cells Against Glioma Cancer Stem Cell Antigens for Patients With Recurrent Glioblastoma

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What is being tested

Activated T cells

Biological
Who is being recruted

Astrocytoma+15

+ Brain Diseases

+ Brain Neoplasms

Over 18 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1
Interventional
Study Start: June 2026
See protocol details

Summary

Principal SponsorJeremy Rudnick, M.D
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 1, 2026

Actual date on which the first participant was enrolled.

The purpose of this study is to examine the use of activated T cells (ATCs) to assess the safety and tolerability of autologous activated T cells, as measured by the number of Grade 3 or higher toxicities, the number of serious adverse events, and treatment-related toxicities, according to National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) Version 5, to find the maximum tolerated dose. The secondary objectives include evaluating the rate of overall survival, rate of progression-free survival, health-related quality of life parameters, overall response rate, immune response, and tumor stem cell antigen expression.

Official TitleA Phase I Trial of Activated Autologous T Cells Against Glioma Cancer Stem Cell Antigens for Patients With Recurrent Glioblastoma
NCT05341947
Principal SponsorJeremy Rudnick, M.D
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AstrocytomaBrain DiseasesBrain NeoplasmsCentral Nervous System DiseasesEpendymomaGlioblastomaGliomaNeoplasmsNeoplasms by Histologic TypeNeoplasms by SiteNeoplasms, Germ Cell and EmbryonalNeoplasms, Glandular and EpithelialNeoplasms, Nerve TissueNervous System DiseasesNervous System NeoplasmsCentral Nervous System NeoplasmsNeuroectodermal TumorsNeoplasms, Neuroepithelial

Criteria

3 inclusion criteria required to participate
Recurrent glioblastoma
HLA-A1 and HLA-A2 positive
Complete resection of tumor
6 exclusion criteria prevent from participating
Clinically significant pulmonary, cardiac or other systemic disease
Presence of an acute infection requiring active treatment with antibiotics/antivirals; prophylactic administration is allowed.
Known human immunodeficiency virus positivity or acquired immunodeficiency syndrome related illness or other serious medical condition.
Known history of Hepatitis B or Hepatitis C
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Cedars-Sinai Medical Center

Los Angeles, United StatesOpen Cedars-Sinai Medical Center in Google Maps
SuspendedOne Study Center