FORTEeInnovative Exercise Treatment for Improved Strength and Quality of Life in Children Undergoing Cancer Treatment

Exercise training

Change in the score of Cancer-related fatigue during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in functional strength after the intervention and after a 12-week follow-up compared to baseline

Change in arm strength after the intervention and after a 12-week follow-up compared to baseline

Change in the score of general Health-Related Quality of Life during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of cancer-related Health-Related Quality of Life during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of Mental Health (measured by WHO (Five) Well-Being Index) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of Mental Health (measured by Warwick-Edinburgh Mental Well-being Scale (WEMWBS)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of Resilience (measured by Mainzer Resilience Scale for childhood cancer (MRScc)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in motor function after the intervention and after a 12-week follow-up compared to baseline

Change in hamstrings flexibility after the intervention and after a 12-week follow-up compared to baseline

Change in the score of Resilience (measured by the Brief Resilience Scale (BRS)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of Resilience (measured by the Child & Youth Resilience Measure-Revised (CYRM-R)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of General self-efficacy during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the score of Physical exercise self-efficacy during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the Physical activity level (measured by the Modifed Recent Physical Activity Questionnaire (mRPAQ)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the Physical activity level (measured by the Modified Youth Physical Activity Questionnaire (mYPAQ)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the Physical activity level (measured by the Modified Children's Physical Activity Questionnaire (mCPAQ)) during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in the Physical activity level and behaviour during the intervention, after the intervention, and over a 1-year follow-up period compared with baseline

Change in functional capacity after the intervention and after a 12-week follow-up compared to baseline

Change in endurance performance (measured by the assisted 6-minute cycling test) after the intervention and after a 12-week follow-up compared to baseline

Change in endurance performance (measured by the adapted Yo-Yo-Test) after the intervention and after a 12-week follow-up compared to baseline

Longitudinal assessment of oxidative skeletal muscle impairment after the intervention and after a 12-week follow-up compared to baseline

Change in peak oxygen uptake (VO2peak) after the intervention and after a 12-week follow-up compared to baseline

Change in lower limbs flexibility after the intervention and after a 12-week follow-up compared to baseline

Change in upper body strength after the intervention and after a 12-week follow-up compared to baseline

Change in knee flexor strength after the intervention and after a 12-week follow-up compared to baseline

Change in leg extension strength after the intervention and after a 12-week follow-up compared to baseline

Change in functional mobility after the intervention and after a 12-week follow-up compared to baseline

Change in static balance after the intervention and after a 12-week follow-up compared to baseline

Change in body composition (measured via skinfold measurement) after the intervention and after a 12-week follow-up compared to baseline

Change of the phase angle by means of bioelectrical impedance analysis for the examination of body composition after the intervention and after a 12-week follow-up compared to baseline

Change in body composition (measured via dual-energy x-ray absorptiometry) after the intervention and after a 12-week follow-up compared to baseline

Usage frequency of the augmented reality (AR) app from baseline to the end of app use

Usability of the augmented reality app

Usability of the pixformance station

Composite multidimensional socioeconomic status index

Change in the number of T-cells before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention

Change in the number of B-cells before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention

Change in the number of NK-cells before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention

Change in the number of leukocytes before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention

Change in the number of monocytes before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention

Change in the DNA methylation status of T cells before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention

Change in the DNA methylation status of NK cells before start of anti-cancer treatment (baseline), pre-exercise intervention and post-exercise intervention (baseline), pre-exercise intervention and post-exercise intervention