[15-O]-H2O PET Imaging for Coronary Artery Disease Diagnosis

This clinical trial is designed to evaluate a new method for diagnosing coronary artery disease (CAD), a condition where the blood vessels that supply the heart with blood become narrowed or blocked. The study focuses on using a special imaging technique called PET imaging, which involves the injection of a substance known as \[15-O\]-H2O. This method is being tested on patients who are suspected to have CAD. The goal is to see if this new imaging technique can accurately identify CAD during both resting and stress conditions. Success in this study could lead to a more effective way to diagnose CAD, potentially improving treatment options and outcomes for patients. Participants in this study will receive two injections of \[15-O\]-H2O during a single imaging session. One injection occurs while the participant is at rest, and the other is given while the participant is under stress induced by a medication called adenosine. The study will measure how accurately the PET imaging results, using \[15-O\]-H2O, identify CAD compared to standard diagnostic methods. After the imaging session, a follow-up phone call will be made to ensure participant safety. This study will help determine the sensitivity and specificity of the new method, which refers to its ability to correctly identify those with and without the disease.