Correlation of Gut Microbiome with Cancer Diagnoses and Therapy Response

This study focuses on understanding the role of gut microbiome in cancer therapy. It aims to find a connection between the gut microbiome and specific types of cancer diagnoses. The study also explores how the gut microbiome might influence the effectiveness and side effects of cancer treatments, including single or multiple therapies and stem cell transplants. This research is important as it could potentially improve cancer treatment strategies by considering the patient's gut microbiome, thereby addressing unmet needs in cancer care. Participants in this study will have their blood and stool samples collected for analysis. Their medical records will also be reviewed. The study will use a special linear multivariate regression model called MaAsLin to identify associations between microbial community abundances and clinical outcomes. Additionally, the Shogun pipeline for metagenomics data followed by analysis using Quantitative Insights Into Microbial Ecology (QIIME) 2.0 will be used to understand the gut microbiome associations with cancer diagnoses.