Recruiting

Parkinson's Progression Markers Initiative Online Study (PPMI Online)

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What is being collected

Data Collection

Who is being recruted

Synucleinopathies+6

+ Basal Ganglia Diseases

+ Brain Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: July 2021
See protocol details

Summary

Principal SponsorMichael J. Fox Foundation for Parkinson's Research
Study ContactUniversity of California, San Francisco
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 28, 2021

Actual date on which the first participant was enrolled.

PPMI is a broad program that is expanding the goals of the original PPMI study, and will include this PPMI Online protocol, as well the PPMI Clinical \[NCT04477785\], PPMI Remote, PPMI Digital protocols (with external regulatory oversight). All participants in PPMI may be asked to participate in one or all of these protocols and their enrollment in these studies may occur in varying order. PPMI participants may also be asked to participate in additional PPMI companion studies (as they are developed), which may only involve a subset of PPMI participants based on their cohort designation

Official TitleParkinson's Progression Markers Initiative Online Study (PPMI Online)
NCT05065060
Principal SponsorMichael J. Fox Foundation for Parkinson's Research
Study ContactUniversity of California, San Francisco
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

500000 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

SynucleinopathiesBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesMovement DisordersNervous System DiseasesParkinson DiseaseNeurodegenerative DiseasesParkinsonian Disorders

Criteria

Inclusion Criteria: * Parkinson Disease (PD) Participants: * Male or female age 18 years or older. * Has received a diagnosis of Parkinson's disease Participants without PD: * Male or female age 18 years or older. * Has not received a diagnosis of Parkinson's disease

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

UCSF Movement Disorders and Neuromodulation Center (MDNC)

San Francisco, United StatesOpen UCSF Movement Disorders and Neuromodulation Center (MDNC) in Google Maps
Recruiting
One Study Center