NBOLNormobaric Hyperoxia and Endovascular Therapy for Stroke within 6 Hours of Onset

This study is about using a treatment called Normobaric Hyperoxia (NBO) combined with Endovascular Therapy (ET) for patients who have experienced a stroke within 6 hours of its onset. The goal is to understand the long-term outcomes of this combined treatment. Stroke patients who are suspected to have blockages in large blood vessels in the front part of the brain are the focus of this study. The importance of this study lies in finding a potential way to protect the brain tissue from damage due to lack of blood supply, which could improve stroke care and outcomes. In this study, patients who are assigned to the NBO+ET group receive high flow oxygen (10L/min) through an oxygen mask, starting in the emergency room immediately after they are randomized into the group. The oxygen is given for 4 hours. This duration is chosen to balance the potential benefits and risks of oxygen inhalation, as longer periods may increase the risk of oxygen poisoning, while shorter periods may not provide enough benefits. The oxygen treatment is ideally started before and continued for a short period after the blood flow is restored. The effectiveness of the treatment is measured using the Modified Rankin Scale, a disability score ranging from 0 (no symptoms) to 6 (death). Patients in the control group breathe room air normally without any additional equipment.