Completed

Intermittent Fasting Impact on Obese CKD Stage 3-4 Patients: A Pilot Study

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Study Aim

This pilot study aims to explore how intermittent fasting can impact the kidney function, measured by eGFR, in obese patients with stage 3-4 Chronic Kidney Disease.

What is being tested

Time-restricted feeding(TRF)

Behavioral
Who is being recruted

Urogenital Diseases+20

+ Intermittent Fasting

+ Behavior

From 18 to 65 Years
+14 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: August 2021
See protocol details

Summary

Principal SponsorGuangdong Provincial Hospital of Traditional Chinese Medicine
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 12, 2021

Actual date on which the first participant was enrolled.

This study focuses on obese patients with Chronic Kidney Disease (CKD) stage 3-4. The goal is to explore the effects of a specific dietary approach called time-restricted feeding, which is a form of intermittent fasting. This diet doesn't limit the amount of food but rather the time when food can be eaten. The idea is to find a safer and more manageable way to delay the progression of kidney disease, as compared to traditional low-protein diets. The study is particularly important as there is limited data on the effects of intermittent fasting on obese CKD patients, especially within the Chinese population. During this trial, participants will follow a time-restricted feeding plan. The study will measure the effectiveness of this diet by tracking changes in eGFR, a test that measures how well the kidneys filter blood. The eGFR at the beginning of the study will be compared to the eGFR at the end of the study. This will help determine if time-restricted feeding can slow down the worsening of kidney function in obese CKD patients. The study will also monitor the safety and compliance of this dietary approach.

Official TitleEffects of Time-restricted Feeding on Obese Patients With Chronic Kidney Disease Stage 3-4: a Pilot Study
NCT05037747
Principal SponsorGuangdong Provincial Hospital of Traditional Chinese Medicine
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

28 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesIntermittent FastingBehaviorBody WeightChronic DiseaseFastingFeeding BehaviorFemale Urogenital Diseases and Pregnancy ComplicationsKidney DiseasesNutrition DisordersNutritional and Metabolic DiseasesObesityPathologic ProcessesSigns and SymptomsPathological Conditions, Signs and SymptomsUrologic DiseasesDisease AttributesOvernutritionOverweightRenal Insufficiency, ChronicRenal InsufficiencyFemale Urogenital DiseasesMale Urogenital Diseases

Criteria

5 inclusion criteria required to participate
Age 18-65 years
CKD stage 3-4 and not on dialysis (eGFR: 15-59ml/min/1.73m2)
BMI ≥ 25 kg/m2
Good reading and comprehension skills, simple smartphone operation and no communication difficulties
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9 exclusion criteria prevent from participating
Pregnant and breastfeeding
End-stage diseases
Acute and active diseases such as gastrointestinal bleeding or acute infections, serious decompensation with diseases such as cirrhosis decompensation stage, malignant tumor, serious heart and lung diseases, severe primary diseases of hematopoietic system, severe hypertension (systolic blood pressure ≥200mmHg, diastolic blood pressure ≥120mmHg) and difficult to control blood pressure, within 3 months after major surgery, such as open surgery
Mental patients
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
The TRF group was asked to restrict the eating window to 8 hours a day, during waking hours and also continue a low-protein diet.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Guangdong Provincial Hospital of Chinese Medicine

Guangzhou, ChinaOpen Guangdong Provincial Hospital of Chinese Medicine in Google Maps
CompletedOne Study Center