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T1rho Magnetic Resonance Imaging in Healthy Brain Parenchyma

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Study Aim

This study aims to measure T1rho values in normal grey and white matter in your healthy brain using T1rho weighted MRI, helping to improve diagnostic techniques.

What is being tested

T1rho imaging

Diagnostic Test
Who is being recruted

Over 18 Years
+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Diagnostic Study

Interventional
Study Start: August 2021
See protocol details

Summary

Principal SponsorChinese University of Hong Kong
Study ContactTiffany So
Last updated: March 25, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2021

Actual date on which the first participant was enrolled.

A new MRI method called T1rho imaging shows promise in brain imaging. This technique doesn't need any special dyes and can produce clear, detailed pictures. The study aims to understand how T1rho imaging appears in the brains of healthy individuals. This research is important as it helps establish a baseline for normal T1rho values in the brain, which could improve diagnosis and treatment of brain conditions in the future. During the study, participants undergo T1rho imaging. This involves measuring T1rho values in different parts of the brain, specifically in normal grey and white matter. The study uses these measurements to evaluate the effectiveness of T1rho imaging in depicting typical brain structures. The potential benefits include a better understanding of brain anatomy using this new imaging technique.

Official TitleQuantitative T1rho Magnetic Resonance Imaging in Healthy Subjects
NCT04993196
Principal SponsorChinese University of Hong Kong
Study ContactTiffany So
Last updated: March 25, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Diagnostic Study

Diagnostic studies focus on improving how we detect or confirm a disease. They test new tools or techniques that could provide faster or more accurate diagnoses.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate
Male and female volunteers greater than or equal to 18 years of age
3 exclusion criteria prevent from participating
Subjects with previous severe allergic or anaphylactoid reaction to a gadolinium contrast agent, or contraindication to contrast gadolinium administration, such severe renal disease or acutely deteriorating renal function, who would be at risk of nephrogenic systemic fibrosis
Subjects who are unable to tolerate the scan without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath
Subjects with a contraindication to magnetic resonance imaging such as the presence of metallic implants, claustrophobia and pregnancy

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

CUHK

Hong Kong, Hong KongOpen CUHK in Google Maps
Recruiting
One Study Center