PHARMATOPTopiramate for Weight Loss in Youth with Severe Obesity

This study focuses on understanding how the drug Topiramate helps with weight loss in young people who have severe obesity. Topiramate is believed to reduce appetite, cravings, and certain eating habits, which may help with losing weight. Researchers aim to find out why Topiramate works better for some individuals than others, by looking at specific factors like age, body mass index (BMI), and sex. This is important because it could lead to more personalized treatments for young people struggling with obesity, potentially improving their health outcomes. Participants in the study will take Topiramate and have their drug levels monitored over a period of 3.5 months to see how it affects their weight and eating behaviors. The study will measure changes in BMI, which is a way to see how much weight a person has lost relative to their height. By using advanced models, researchers will analyze how the drug exposure correlates with changes in weight and eating patterns. This will help determine if certain characteristics make the drug more effective for some young individuals, paving the way for tailored obesity treatments. The study involves regular check-ins and measurements, ensuring safe monitoring of participants' health throughout the process.