Recruiting

Myocardial Work Assessment in Overweight and Obese Adults

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Study Aim

This study aims to observe and assess changes in various aspects of heart function, such as global constructive work, global myocardial work index, global waste work, and global work efficiency, in overweight or obese adults, comparing the results with those of lean individuals.

What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Body Weight+5

+ Nutrition Disorders

+ Nutritional and Metabolic Diseases

From 18 to 70 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: May 2019
See protocol details

Summary

Principal SponsorRenJi Hospital
Study ContactHang Zhao
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2019

Actual date on which the first participant was enrolled.

This study focuses on the impact of obesity on heart health. It's widely known that being overweight or obese can increase the risk of heart failure. The study aims to detect early signs of heart dysfunction in individuals with overweight or obesity and explore its connection with insulin resistance. A new method for assessing heart performance, called myocardial work (MW), is being used. The goal is to understand how MW changes in overweight or obese adults and if insulin resistance or other clinical risk factors might affect heart function before significant issues arise. During the study, researchers will measure different aspects of heart function in overweight or obese individuals and compare them with lean individuals. These aspects include global constructive work (GCW), global myocardial work index (GWI), global waste work (GWW), and global work efficiency (GWE). These measurements help understand how efficiently the heart is working. All measurements are obtained through echocardiography, a non-invasive procedure that uses sound waves to create images of the heart. The study hopes to provide valuable insights into the early detection and prevention of heart disease in overweight or obese individuals.

Official TitleEarly Detection of Myocardial Work Impairment in Patients With Overweight and Obesity (EARLY-MYO-OBESITY-II)
NCT04933188
Principal SponsorRenJi Hospital
Study ContactHang Zhao
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

200 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Body WeightNutrition DisordersNutritional and Metabolic DiseasesObesitySigns and SymptomsPathological Conditions, Signs and SymptomsOvernutritionOverweight

Criteria

3 inclusion criteria required to participate
All patients were older than 18 without any cardiac symptoms.
The diagnosis of overweight was established when body mass index (BMI) of 25 to 30 kg/m2.
Obese was defined as a BMI of 30 kg/m2 or higher.
10 exclusion criteria prevent from participating
diagnosis of type 2-Diabetes Mellitus according to the American Diabetes Association criteria;
left ventricular ejection fraction<50% on echocardiography;
arrythmia on electrocardiogram;
severe valvular stenosis or regurgitation;
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Renji Hospital

Shanghai, ChinaOpen Renji Hospital in Google Maps
Recruiting
One Study Center