Completed

N21-1Effects of nooLVL Ingestion on Reaction Time and Cognitive Function in Gamers

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What is being tested

Arginine

+ Placebo

Dietary Supplement
Who is being recruted

From 18 to 40 Years
+20 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Services Research Study

Placebo-Controlled
Interventional
Study Start: April 2020
See protocol details

Summary

Principal SponsorTexas A&M University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 6, 2020

Actual date on which the first participant was enrolled.

Gaming or "E-Sports" has become a very popular activity particularly among younger individuals. It requires quick reactions, executive function, memory and fine motor skill. In E-Sport competitions and tournaments, E-Sport players often play for hours per session over a series of days. Thus, the ability to maintain cognitive and executive function, concentration and fine motor skill is paramount. Two recent studies have evaluated the effects of ingesting bonded arginine silicate (ASI) and ASI with additional inositol on cognitive function. In the first study, ASI supplementation (1,500 mg/d for 3 days and 14 days) significantly improved the ability to perform complex cognitive tests requiring mental flexibility, processing speed and executive functioning. In the second study, adding 100 mg of inositol to the ASI significantly improved cognitive function in gamers after playing video games for one hour. This study is designed to assess the effects of bonded arginine silicate and inositol ingestion on reaction time and cognitive function prior to and following a 1-hour gaming challenge.

Official TitleEffects of nooLVL Ingestion on Reaction Time and Cognitive Function in Gamers
NCT04828278
Principal SponsorTexas A&M University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

24 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Services Research Study

These studies look at how healthcare is delivered, managed, and organized. They aim to improve care quality, patient experience, and access to treatment.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

5 inclusion criteria required to participate
They are a healthy male or female Gamer 18 to 40 years of age;
They have a Body Mass Index (BMI) between 18 and 34.9 kg/m2;
They are willing to supply their own operator-oriented action or stragegy video game that they have played 21 times over the last 3 months and the gaming platform with all accessories needed to play the chosen game;
They report no recent ingestion (<2 weeks) of dietary supplements that affect cognitive function including nitrates and nitrous oxide (NO2) promoting supplements;
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15 exclusion criteria prevent from participating
They have guanidinoacetate methyltransferase deficiency;
They have known cardiovascular, metabolic and/or other diseases under the treatment of a physician requiring prescription (Rx) medication (birth control is allowed);
They have a history of cognitive dysfunction;
They have a known allergy to maltodextrin;
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
1,500 mg of ASI (bonded arginine silicate) + 100 mg of inositol (nooLVL)

Group II

Placebo
1,600 mg of Placebo (maltodextrin)

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Human Clinical Research Facility

College Station, United StatesOpen Human Clinical Research Facility in Google Maps
CompletedOne Study Center