Suspended

Telehealth Intervention for Childhood Cancer Survivors with Limited Exercise Tolerance

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Study Aim

This study aims to assess if a telehealth intervention can improve exercise capacity in childhood cancer survivors who have limited exercise tolerance.

What is being tested

Exercise testing results

+ Generalized exercise recommendations (AC)

+ Individually tailored exercise program (INT)

Other
Who is being recruted

Neoplasms+1

+ Signs and Symptoms

+ Pathological Conditions, Signs and Symptoms

From 18 to 39 Years
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: February 2021
See protocol details

Summary

Principal SponsorSt. Jude Children's Research Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 8, 2021

Actual date on which the first participant was enrolled.

This study aims to enhance the ability to exercise for people who have survived childhood cancer but now face challenges with physical activity. These individuals often experience limited exercise tolerance, which can impact their overall health and quality of life. By using telehealth, the study hopes to provide more accessible support and tailored exercise programs that could potentially improve their physical capabilities. This approach is significant because it could lead to better long-term health outcomes for childhood cancer survivors. Participants in this study are randomly divided into two groups. One group receives a personalized exercise program created by an exercise specialist, while the other group receives general exercise advice based on the Physical Activity Guidelines for Americans. The study uses performance tests to measure exercise capacity, focusing on changes and sustainability in peak oxygen usage (VO2) and performance in a simple step test. This research evaluates how effective each approach is in improving exercise capacity, providing valuable insights into managing exercise limitations in this population.

Official TitleTelehealth Based Intervention to Improve Functional Capacity in Survivors of Childhood Cancer With Significantly Limited Exercise Tolerance
NCT04714840
Principal SponsorSt. Jude Children's Research Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

181 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 39 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

NeoplasmsSigns and SymptomsPathological Conditions, Signs and SymptomsMobility Limitation

Criteria

Inclusion Criteria: * Between 18.00 and 39.99 years of age at the time of enrollment * SJLIFE participant * Peak VO2 \<85% predicted * Verbalizes understanding of directions for use of ZOOM on the study provided iPad and heart rate monitor * Clearance for participation in exercise by a study physician * Internet access Exclusion Criteria: * Enrolled in a formal exercise intervention * Self-report of engaging in \> 150 minutes/week of moderate physical activity * Currently pregnant (assess by urine pregnancy test) * Significant psychological distress (e.g. suicidal ideation) * Requires immediate medical intervention (e.g. angina, decompensated heart failure) * Research Participant Recruitment and Screening

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Study participants in this group receive generalized exercise recommendations, 20 weeks,clinic 3 times during the course of this study: at baseline (this appointment), at 4 months and 10 months from now for follow-up.

Group II

Participants in this group have individually tailored exercise program with supervision, 20 weeks,clinic 3 times during the course of this study: at baseline (this appointment), at 4 months and 10 months from now for follow-up.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

St. Jude Children's Research Hospital

Memphis, United StatesOpen St. Jude Children's Research Hospital in Google Maps
SuspendedOne Study Center
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