PAWSEffects of Acetaminophen on Pain Response Among Overweight or Obese Women Exposed to Weight Stigmatization
Data Collection
Collected at a single point in time - Cross-sectionalWeight Prejudice+12
+ Behavior
+ Body Weight
Other
Utilizing specific methods not covered by standard models in order to address unique research questions.Summary
Study start date: November 15, 2019
Actual date on which the first participant was enrolled.The purpose of this study is to evaluate the influence of weight stigma on emotional functioning and biomarkers of inflammation among overweight and obese women; and to determine the degree to which acetaminophen moderates the stigma-related effects. Participants will provide blood spot and saliva samples upon arrival, and then be randomly assigned to consume either 1,000mg of acetaminophen in liquid form, or a placebo solution. Participants then will complete a series of questionnaires assessing a variety of relevant psychological and behavioral constructs. After this participants will be randomly assigned to read one of two shorts stories and answer a series of questions about their reaction to the story. Finally, participants will answer another series of questionnaires and provide a second saliva sample. Participants will first be adult women in the Columbus, Ohio and surrounding areas with body mass indices considered overweight or obese. A smaller cohort of women with normal weight will be recruited at a later time for purposes of comparison.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.200 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Other
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Female
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * At least 18 years old and biologically female Exclusion Criteria: * Due to the use of acetaminophen in this study, women who report current pregnancy will be excluded from the study due to potential negative effects on pregnancy. The following are additional exclusion criteria: 1. Visual impairment that would impair one's ability to read to the extent that they could not read items on paper or a computer screen. 2. Stopping schooling prior to completing ninth grade. 3. A history of liver disorder and/or alcohol abuse. 4. A current prescription of a drug that contains acetaminophen. 5. Allergy to acetaminophen 6. A score on the Patient Health Questionnaire - 9 depressive symptom scale of 15 or greater. 7. For normal weight participants, a history of overweight or obesity.
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location