Completed

The Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic Gastrectomy: Prospective, Double Blind Placebo-controlled Study

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What is being tested

Mosapride citrate

+ Placebo

Drug
Who is being recruted

Tissue Adhesions+13

+ Cicatrix

+ Digestive System Diseases

From 18 to 79 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: July 2020
See protocol details

Summary

Principal SponsorGangnam Severance Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 27, 2020

Actual date on which the first participant was enrolled.

"Mosapride citrate is a 5-hydroxytryptamine 4 receptor agonist, and is widely used as an agent to increase intestinal motility. Mosapride citrate has been demonstrated in in vitro and in vivo studies to increase both gastric and colon motility. In a case-control study of patients undergoing colonectomy, mosapride citrate was found to significantly reduce gas passing and defecation time. Recently, a study reported that mosapride citrate acts on the α7nACh receptor and, consequently, suppresses the inflammatory response of macrophages, thereby suppressing the mechanism that induces paralysis after surgery. To date, this study is intended to analyze whether mosapride citrate significantly affects the improvement of bowel movement after surgery after gastrectomy."

Official TitleThe Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic Gastrectomy: Prospective, Double Blind Placebo-controlled Study
NCT04493125
Principal SponsorGangnam Severance Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

104 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 79 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Tissue AdhesionsCicatrixDigestive System DiseasesDigestive System NeoplasmsFibrosisGastrointestinal DiseasesGastrointestinal NeoplasmsIntestinal DiseasesIntestinal ObstructionNeoplasmsNeoplasms by SitePathologic ProcessesStomach DiseasesStomach NeoplasmsPathological Conditions, Signs and SymptomsIleus

Criteria

3 inclusion criteria required to participate
Patients diagnosed with gastric cancer pathologically before surgery
Patients who underwent surgical resection (R0 resection)
Patients with an ASA score of 3 or less
8 exclusion criteria prevent from participating
Patients over 80 years old
When there are multiple or peritoneal metastases
Intestinal obstruction before surgery
When chemotherapy was performed before surgery
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Patients receive placebo or mosapride citrate (5mg/T) three times a day from the first day after surgery.

Group II

Placebo
Patients receive placebo instead of mosapride citrate (5mg/T) three times a day from the first day after surgery

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

GangnamSeverance Hospital

Seoul, South KoreaOpen GangnamSeverance Hospital in Google Maps
CompletedOne Study Center