Pharmacokinetics and Bioavailability Comparison of Novel Furosemide Regimen in Chronic Heart Failure Patients

This study focuses on comparing the effectiveness of a new way to administer furosemide, a common heart failure medication, in adults with mild to moderate heart failure. Currently, furosemide is often given orally or through an IV. The study aims to test a novel method of delivering the drug subcutaneously, or under the skin, and compare it to the traditional IV method. The goal is to see if this new method can provide the same benefits as the IV method, potentially making treatment more convenient and comfortable for patients. This research is important as it could lead to improved care and quality of life for individuals with heart failure. During the study, participants will be randomly assigned to receive furosemide either subcutaneously or intravenously, and then will switch to the other method after a short break. This is known as a 'crossover' study design. Participants will need to stay in a clinical research unit for each treatment period and will be asked to limit their sodium intake before each visit. The study will measure how well the body absorbs and uses the drug under each delivery method. This is done by comparing the 'area under the curve' (AUC) of furosemide in the bloodstream after subcutaneous and IV administration. The AUC is a standard way to measure how much of a drug is in the body over a certain period of time.