Completed

AIPLAInvestigating the Role of Animal-assisted Intervention and Placebo-induced Analgesia in Pain Management

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What is being tested

Animal-assisted placebo condition

+ Placebo condition

+ Dog only condition

Other
Who is being recruted

Neurologic Manifestations+1

+ Pain

+ Signs and Symptoms

From 18 to 65 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: June 2020
See protocol details

Summary

Principal SponsorUniversity Hospital, Basel, Switzerland
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 15, 2020

Actual date on which the first participant was enrolled.

Animal-assisted interventions (AAI) are becoming popular in clinical settings due to their potential benefits, such as reducing stress, depression, anxiety, and pain. However, it's unclear how these interventions work or what makes them effective. This study aims to understand if the presence of an animal enhances the therapeutic alliance, or if it's the therapeutic rationale and relationship that play a crucial role. The researchers will investigate if AAI works similarly to placebo effects, which are related to therapeutic rationale and relationship. This study is important as it could provide insights into how AAI should be used effectively in clinical practice. The study involves 128 healthy participants and uses a standardized heat pain test. Participants will rate their pain intensity and unpleasantness on a scale of 1 to 10 after each pain stimulus. Heat stimuli will be applied to the right forearm using a device that gradually increases heat. Participants will be asked to stop the heat when they can no longer stand it. This process will be repeated three times, and the average will be used to determine heat tolerance. The study's findings could have significant implications for understanding the mechanisms of AAI and its effective use in clinical settings.

Official TitleCombining Animal-assisted Intervention and Placebo-induced Analgesia: The Dog as Treatment in a Randomized Controlled Trial
NCT04361968
Principal SponsorUniversity Hospital, Basel, Switzerland
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

128 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Neurologic ManifestationsPainSigns and SymptomsPathological Conditions, Signs and Symptoms

Criteria

2 inclusion criteria required to participate
Age ≥ 18 years

Right-handedness

8 exclusion criteria prevent from participating
Pregnancy

Insufficient German language skills to understand the instructions

Being scared of dogs by self-report

dog hair allergy by self-report

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

4 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants receive verbal information that they are receiving an analgesic cream. Additionally, and before getting the dog, participants will get a therapeutic rationale for the presence of the dog.

Group II

Experimental
Participants receive verbal information that they are receiving an analgesic cream.

Group III

Experimental
Before meeting the dog, participants will get a therapeutic rationale for the presence of the dog.

Group IV

Participants in this condition will receive no intervention.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Division of Clinical Psychology and Psychotherapy, University of Basel

Basel, SwitzerlandOpen Division of Clinical Psychology and Psychotherapy, University of Basel in Google Maps
CompletedOne Study Center