Alpha Lipoic Acid Treatment for Diabetic Peripheral Neuropathy: Impact on Metabolic Parameters

This study focuses on the potential benefits of Alpha Lipoic Acid (ALA) for individuals with type 2 diabetes who also have peripheral neuropathy, a condition that causes nerve damage, typically in the hands and feet. The research takes place at Benha University Hospital and spans three months. Participants must have a stable treatment regimen with ALA. The goal is to understand how ALA might affect various metabolic parameters and peripheral neuropathy symptoms, potentially improving diabetes management. During the study, participants undergo two visits: one before starting ALA treatment and another after three months. Each visit involves a full neurological evaluation, physical examination, and laboratory tests. The evaluations include assessment of reflexes, nerve function tests, and blood tests to measure HbA1C, HDL-C, and LDL-C levels. The primary outcomes measured include changes in ankle reflex, nerve conduction velocity, nerve cross-sectional area, and vibration perception. The study also monitors the concentration of Hemoglobin A1c, an indicator of average blood sugar levels, and the levels of good (HDL-C) and bad (LDL-C) cholesterol.