Completed

Effects of NAD3 Supplementation on Biomarkers of Anti-Aging in Healthy Men and Women

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What is being tested

NAD3

Dietary Supplement
Who is being recruted

From 40 to 60 Years
+21 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Placebo-Controlled
Interventional
Study Start: June 2020
See protocol details

Summary

Principal SponsorThe Center for Applied Health Sciences, LLC
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 8, 2020

Actual date on which the first participant was enrolled.

This is a randomized, parallel-group, placebo-controlled, clinical trial in middle-aged and older male and female subjects from Ohio. Subjects will take an over-the-counter dietary supplement or a placebo for 12 weeks. Outcome measures will include body weight, systolic and diastolic blood pressure, standard blood chemistries (e.g. chemistry panel, lipid panel, CBC with differential), changes in mood, vitality, energy, fatigue, productivity, digestive wellness (via anchored Visual Analogue Scales).

Official TitleEffects of NAD3 Supplementation on Biomarkers of Anti-Aging in Healthy Men and Women
NCT04276948
Principal SponsorThe Center for Applied Health Sciences, LLC
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

45 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 40 to 60 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

7 inclusion criteria required to participate
Provide voluntary signed and dated informed consent.
Be in good health as determined by medical history, physical, and routine blood chemistries.
Age between the ages of 40 and 60 (inclusive).
Body Mass Index (BMI) of 18.5-34.9 kg/m2 (normal to Class I obesity).
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14 exclusion criteria prevent from participating
History of uncontrolled diabetes.
Regular use/consumption (i.e. at least 5 days/week) of resveratrol, quercetin, pterostilbene coQ10, grapefruit, nicotinamide riboside, probiotics, prebiotic fiber, green tea, niacin (vitamin B3), multivitamin/multimineral or products meant to promote "healthy aging" or "anti-aging" or "longevity" products in the 2 weeks prior to screening as well as throughout the study.
Clinically significant abnormal blood work at screening.
Consumption of > 2 alcoholic drinks per day.
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

33.333% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
312 mg dose of active

Group II

Experimental
812 mg dose of active

Group III

Placebo
placebo

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

The Center for Applied Health Sciences

Canfield, United StatesOpen The Center for Applied Health Sciences in Google Maps
CompletedOne Study Center