Completed

ADE-RED Score for Predicting ADE-Related Hospitalizations in ED Patients

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Study Aim

This study aims to observe the frequency of hospital readmissions within 30 days due to Adverse Drug Events (ADEs) in patients who have previously visited the Emergency Department.

What is being collected

Data Collection

Collected from past medical records and data - Retrospective
Who is being recruted

Chemically-Induced Disorders

+ Drug-Related Side Effects and Adverse Reactions

+3 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Case-Only

Examining characteristics of individuals with a disease in order to identify genetic or environmental factors contributing to the condition.
Observational
Study Start: November 2019
See protocol details

Summary

Principal SponsorMethodist Health System
Last updated: March 25, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 8, 2019

Actual date on which the first participant was enrolled.

Adverse drug events (ADEs) are unwanted effects caused by medications, which can sometimes lead to hospital admissions. This study focuses on a tool called ADE-RED, designed to predict the risk of hospitalization due to ADEs for patients visiting the emergency department (ED). The tool is particularly useful for identifying high-risk patients, considering factors like age, use of multiple medications, specific high-risk medications, previous ED visits, existing health conditions, and the reason for the current visit. The goal is to improve patient care and reduce the number of preventable ADE-related hospitalizations, which can cause additional harm and cost to patients. In this observational study, the ADE-RED score is used to identify patients at high risk for ADE-related hospitalizations. When a patient scores 12 or more, ED pharmacists perform a thorough review of the patient's medications and make necessary recommendations to the medical team. The primary outcome of the study is to compare the incidence of ADE-related readmissions within 30 days of a prior ED visit using the ADE-RED score, with the incidence observed in other facilities within the Methodist Health System. This comparison helps evaluate the effectiveness of the ADE-RED score in predicting and reducing ADE-related hospital readmissions.

Official TitleEffectiveness of an ADE-related Hospitalization Risk Prediction Tool for Patients Discharged From the Emergency Department (ADE-RED)
NCT04181775
Principal SponsorMethodist Health System
Last updated: March 25, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

471 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Case-only

These studies focus only on individuals who have a specific disease. Researchers examine patterns—often genetic or environmental—to uncover what might be linked to the condition.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Chemically-Induced DisordersDrug-Related Side Effects and Adverse Reactions

Criteria

2 inclusion criteria required to participate
Patients admitted to the hospital with a prior ED visit within the previous 30 days

Patients presenting to the ED with a prior ED visit within the previous 30 days

1 exclusion criteria prevent from participating
Patients without PTA medications at the time of initial ED presentation

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Methodist Dallas Medical Center

Dallas, United StatesOpen Methodist Dallas Medical Center in Google Maps
CompletedOne Study Center