Dr. Pao-Lin Kuo (Department of Obstetrics and Gynecology)

This study focuses on Recurrent Miscarriage (RM) and Hydatidiform Mole (HM), conditions that affect 1% to 5% of couples and 1 in every 1500 pregnancies in the West, respectively. RM is defined as two or more consecutive miscarriages before the 20th week of pregnancy, while HM is a rare mass or growth that forms inside the uterus at the beginning of a pregnancy. The exact causes of RM and HM are unknown in most cases. However, research suggests that the NLRP family of genes, particularly NLRP7, may play a significant role. These genes are known for their roles in apoptosis (cell death) and inflammation, and they express differently in human eggs and early embryonic cells. Mutations in NLRP7 have been found in women experiencing repeated molar pregnancies, stillbirths, or early miscarriages, suggesting it as a strong candidate gene for RM/HM. This study aims to understand these genetic links better, potentially improving care and addressing the challenges faced by affected couples. The study is observational, meaning participants will not receive any specific treatment. Instead, the researchers will observe and record the outcomes of pregnancies. The primary outcome measured is the delivery of a normal baby, which is considered a normal pregnancy outcome. This study does not mention any potential risks, but it aims to provide valuable insights into the role of NLRP7 in RM and HM, which could lead to improved understanding and care for these conditions.