Completed

Efficacy of Extract of Trigonella Foenum-graceum (Fenugreek) as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women : A Study of COL1A1, COL3A1, Skin Thickness, and Skin Wrinkles

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Trigonella foenum-graceum extract topical cream

+ Facial Wash

+ Sunscreen Cream

DrugOther
Who is being recruted

+14 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-ControlledPhase 1 & 2
Interventional
Study Start: August 2019
See protocol details

Summary

Principal SponsorIndonesia University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 10, 2019

Actual date on which the first participant was enrolled.

In this double-blinded unmatched randomized controlled trial, the investigators intend to study the efficacy of Trigonella foenum-graceum extract as topical phytoestrogen in skin aging treatment of post menopausal women. The investigators have gathered 21 participants that will be divided into 2 groups, experimental group and control group. Experimental group will get treatment with topical cream containing Trigonella foenum-graceum extract, while control group will get treatment with placebo cream. The study will be held in esthetic cluster, Kencana Cipto Mangunkusumo Hospital, and radiology cluster, Kencana Cipto Mangunkusumo Hospital from August 2019 until November 2019.

Official TitleEfficacy of Extract of Trigonella Foenum-graceum (Fenugreek) as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women : A Study of COL1A1, COL3A1, Skin Thickness, and Skin Wrinkles
NCT04123743
Principal SponsorIndonesia University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

21 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Female

Biological sex of participants that are eligible to enroll.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

5 inclusion criteria required to participate
Women with minimum 2 years post menopausal and maximum 8 years post menopausal
Have skin aging problems that manifested as wrinkles on forehead, crow's feet, and nasolabial fold region
Estradiol level < 30 pg/mL
Willing to terminate the routine use of facial cream or treatment during the study duration and at least for 30 days before the study commence
Show More Criteria
9 exclusion criteria prevent from participating
Using oral/topical hormonal supplement in the last 12 months
Dermatitis in the region of face
Using products containing retinoic acid or it's derivatives in the last 30 days
Underwent radiotherapy, facelift, dermabrasion, botox, or facial filler procedures in the last 5 years
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
The experimental group will be given topical cream containing Trigonella foenum-graceum extract, Wardah brand facial wash, and Parasol sunscreen SPF 33.

Group II

Placebo
The control / placebo group will be given placebo topical cream, Wardah brand facial wash, and Parasol sunscreen SPF 33

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Faculty of Medicine, Universitas Indonesia

Jakarta Pusat, IndonesiaOpen Faculty of Medicine, Universitas Indonesia in Google Maps
CompletedOne Study Center