Recruiting

A Registered Cohort Study on Wilson's Disease

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Basal Ganglia Diseases+15

+ Brain Diseases

+ Brain Diseases, Metabolic

See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: July 2019
See protocol details

Summary

Principal SponsorWan-Jin Chen
Study ContactJin He, MDMore contacts
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2019

Actual date on which the first participant was enrolled.

The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.

Official TitleA Registered Cohort Study on Wilson's Disease
NCT04012658
Principal SponsorWan-Jin Chen
Study ContactJin He, MDMore contacts
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

2000 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Basal Ganglia DiseasesBrain DiseasesBrain Diseases, MetabolicCentral Nervous System DiseasesDigestive System DiseasesHepatolenticular DegenerationLiver DiseasesMetabolic DiseasesMetabolism, Inborn ErrorsMetal Metabolism, Inborn ErrorsMovement DisordersCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesNervous System DiseasesNutritional and Metabolic DiseasesNeurodegenerative DiseasesHeredodegenerative Disorders, Nervous SystemBrain Diseases, Metabolic, InbornGenetic Diseases, Inborn

Criteria

Inclusion Criteria: * Patients with the genetic diagnosis of Wilson's Disease * Asymptomatic Wilson's Disease carriers * Relatives of Wilson's Disease patients or carriers * Unrelated healthy controls * Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process Exclusion Criteria: \* Participants are unable to comply with study procedures and visit schedule

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

First Affiliated Hospital of Fujian Medical University

Fuzhou, ChinaOpen First Affiliated Hospital of Fujian Medical University in Google Maps
Recruiting
One Study Center