BulleEchoLung Ultrasound Characterization of Bullous Emphysema
Data Collection
Collected from today forward - ProspectiveChronic Disease+6
+ Lung Diseases
+ Lung Diseases, Obstructive
Case-Control
Comparing exposures between individuals with and without disease in order to identify potential risk factors.Summary
Study start date: June 26, 2019
Actual date on which the first participant was enrolled.Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease affecting a growing number of adults in the world which is responsible for a large public health burden through heavy morbidity and mortality. Emphysema is one of a wide spectrum of pulmonary complications linked to COPD, defined as the abnormal permanent enlargement of the airspaces distal to the terminal bronchioles accompanied by destruction of the alveolar wall. Disease progression is correlated to worsening and enlargement of emphysema lesions, sometimes conflating in sizeable bullae, deleterious to normal mechanical pulmonary function. Bullous emphysema (BE) is sometimes eligible to invasive curative treatment through surgery or interventional bronchoscopy. Diagnosis of BE relies on computerized tomodensitometry (CT), the gold-standard for evaluating pulmonary parenchyma. However, CT is not always available, and bullous emphysema can present as pneumothorax on chest radiography. The practice of lung ultrasound is currently growing in respiratory medicine and emergency departments owing to an increasing amount of evidence showcasing its reliability as a diagnostic tool, most notably for pneumothorax and other pleural diseases. Despite BE having been reported to present similarly to pneumothorax in ultrasound, its characteristics have not yet been precisely described. The primary aim of this study is to describe BE using lung ultrasound. Participants with known BE on CT will undergo a simple ultrasound examination. The secondary aim is to compare the characteristics of BE to those of pneumothorax using lung ultrasound. To achieve this, a second group of participants with currently treated pneumothorax will also undergo lung ultrasound.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.35 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Case-Control
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Bullous emphysema group * Consultation or scheduled hospitalization in a Pulmonary Medicine department * Past medical history of emphysema on computerized tomodensitometry dating less than two years * Bullous emphysema with subpleural contact of two or more intercostal spaces on tomodensitometry * Pneumothorax group * Hospitalized in a Pulmonary Medicine department for the treatment of a pneumothorax * Patent pneumothorax visible on chest x-ray dating less than 24 hours Exclusion Criteria: * Bullous emphysema group * Current pneumothorax * Past medical history of pleurodesis or pleural thickening homolateral to the bullous emphysema * All patients * Organ failure (hemodynamic, neurological, respiratory) * Recent thoracic surgery dating less than 7 days with subcutaneous emphysema * Minor participant or otherwise deprived of their freedom or their ability to consent freely * No affiliation to social security
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital
Rouen, FranceOpen Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital in Google Maps