Suspended

EXLIPSEEXplanted LIver and Ex-vivo Pancreatic Specimen Evaluation by 7 TESLA MRI - The EXLIPSE Study

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What is being tested

7T Magnetic Resonance Imaging

Diagnostic Test
Who is being recruted

Adenocarcinoma+17

+ Carcinoma

+ Digestive System Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: May 2019
See protocol details

Summary

Principal SponsorUniversity of Pisa
Study ContactLaura Crocetti, MD,PhDMore contacts
Last updated: January 27, 2026
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Study start date: May 24, 2019

Actual date on which the first participant was enrolled.

Aim of this study is to evaluate the correlation between the characteristics detected by the 7T MRI equipment and the histological composition of native explanted livers (group A), liver graft excluded for donation (group B) and surgical specimens of primary pancreatic tumour, which underwent pancreaticoduodenectomy (group C).

Official TitleEXplanted LIver and Ex-vivo Pancreatic Specimen Evaluation by 7 TESLA MRI - The EXLIPSE Study
NCT04012021
Principal SponsorUniversity of Pisa
Study ContactLaura Crocetti, MD,PhDMore contacts
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AdenocarcinomaCarcinomaDigestive System DiseasesDigestive System NeoplasmsEndocrine System DiseasesEndocrine Gland NeoplasmsFatty LiverFibrosisCarcinoma, HepatocellularLiver CirrhosisLiver DiseasesLiver NeoplasmsNeoplasmsNeoplasms by Histologic TypeNeoplasms by SiteNeoplasms, Glandular and EpithelialPancreatic DiseasesPancreatic NeoplasmsPathologic ProcessesPathological Conditions, Signs and Symptoms

Criteria

GROUP A of Native Liver Inclusion Criteria: * informed consent * full possession of one's faculties * patients who are going to undergo liver transplantation, independently from previous therapy or from the primary disease they are affected by. Exclusion Criteria: * patients affected by polycystic liver disease * excluded from liver transplantation. GROUP B of Excluded Grafts Inclusion Criteria: \- liver grafts with histologically proven macrovescic steatosis, not fit for transplantation Exclusion Criteria: * liver grafts histologically proven macrovescic steatosis fit for transplantation * liver grafts not fit for transplantation due to causes other than steatosis GROUP C of Focal Pancreatic Lesion Inclusion Criteria: * informed consent * full possession of one's faculties * pancreatic lesion assessed by CT examination and histologically proved, which are candidates for pancreaticoduodenectomy or total pancreatectomy Exclusion Criteria: \- excluded from surgery due to the severity of their condition.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Three groups of ex-vivo surgical specimen: Group A: native livers in transplant recipients Group B: liver grafts excluded for donation Group C: primary pancreatic cancer

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Azienda Ospedaliero Universitaria Pisana

Pisa, ItalyOpen Azienda Ospedaliero Universitaria Pisana in Google Maps
SuspendedOne Study Center