Suspended

Prognosis and Integrative Assessment of Aortic Coarctation Patients in CHINA

What is being collected

Data Collection

DNA Samples

Who is being recruted

Congenital Abnormalities+4

+ Aortic Coarctation

+ Cardiovascular Diseases

Until 17 Years

+4 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.

Observational

Study Start: March 2019

See protocol details

Summary

Principal SponsorBeijing Institute of Heart, Lung and Blood Vessel Diseases

Study ContactYuan WANG, PhDMore contacts

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: March 1, 2019

Actual date on which the first participant was enrolled.

The goal is to determine how much the left ventricle remodeling pre-operation and how it changes in the following-up duration after surgery, so does in the blood pressure and heart function. Risk factors associated with complications and prognosis are investigated and analyzed. Identification of novel biomarkers is needed to help predicting the prognosis, such as the left ventricle anti-remodeling, heart function and blood pressure improvement, as well as the exercise tolerance post-operation. The findings of this study will help the investigators developping new tests to monitor affected patients and optimize the operation as well as the follow-up procedure.

Official TitlePrognosis and Integrative Assessment of Aortic Coarctation Patients in CHINA

NCT04011956

Principal SponsorBeijing Institute of Heart, Lung and Blood Vessel Diseases

Study ContactYuan WANG, PhDMore contacts

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

300 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Until 17 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Congenital AbnormalitiesAortic CoarctationCardiovascular DiseasesHeart Defects, CongenitalHeart DiseasesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesCardiovascular Abnormalities

Criteria

2 inclusion criteria required to participate

Diagnosis of isolated coarctation of the aorta, or accompanied with atrial septal defect(ASD), ventricular septal defect (VSD), patent ductus arteriosus( PDA), patent foramen ovale (PFO);

Patients who can cooperation with study procedures.

2 exclusion criteria prevent from participating

Co-morbidities that may independently affect cardiovascular function, including associated complicated congenital heart disease, such as hypoplastic left heart syndrome (HLHS), interruption of aortic arch (IAA), Shone Syndrome, moderate and severe mitral stenosis;

History of known vasculopathy, genetic syndromes, diabetes mellitus, hyperlipoidemia or other cardiovascular risk factors.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Beijing Anzhen Hospital

Beijing, ChinaOpen Beijing Anzhen Hospital in Google Maps

SuspendedOne Study Center