Recruiting

TACTIC CRTA Prospective Randomised Multi-centre Trial Comparing cArdiac MRI Guided CRT Versus Conventional CRT Implantation in Patients With Ischaemic Cardiomyopathy

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What is being tested

Guide CRT Software Prototype

Device
Who is being recruted

Cardiovascular Diseases

Over 18 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2019
See protocol details

Summary

Principal SponsorGuy's and St Thomas' NHS Foundation Trust
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 5, 2019

Actual date on which the first participant was enrolled.

The purpose of the study is to determine whether MRI guided CRT implantation (using Siemen's software prototype) is superior to standard treatment in terms of CRT response. Data will be collected at enrolment, implant, pre-discharge, 6 weeks and 6 months. The total duration of the investigation will be 6 months. The primary endpoint will be assessed by calculating the difference in the proportion of responders (>15% reduction in end systolic volume derived from 2-dimensional transthoracic echocardiogram at 6 months post CRT implant).

Official TitleA Prospective Randomised Multi-centre Trial Comparing cArdiac MRI Guided CRT Versus Conventional CRT Implantation in Patients With Ischaemic Cardiomyopathy
NCT03992560
Principal SponsorGuy's and St Thomas' NHS Foundation Trust
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

218 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Cardiovascular Diseases

Criteria

5 inclusion criteria required to participate
18yrs of age
Standard indication for CRT-P or CRT-D according to European Society of Cardiology (ESC)/European Heart Rhythm (EHRA) guidelines.1
Stable on optimal medical therapy for at least 3 months
Ischaemic aetiology
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8 exclusion criteria prevent from participating
Requirement for endocardial pacing
Any contraindication to pacing /implantable cardioverter-defibrillator (ICD) implant
Contraindication to gadolinium contrast enhanced cardiac Magnetic Resonance (MR) scanning
Significant claustrophobia
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Guys and St Thomas NHS Foundation Trust

London, United KingdomOpen Guys and St Thomas NHS Foundation Trust in Google Maps
Recruiting
One Study Center