Suspended

TMSXHRVEffects of Repetitive Transcranial Magnetic Stimulation on Heart Rate Variability

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What is being tested

Repetitive transcranial magnetic stimulation

Procedure
Who is being recruted

From 18 to 35 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: April 2018
See protocol details

Summary

Principal SponsorUniversity of Sao Paulo
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 1, 2018

Actual date on which the first participant was enrolled.

Repetitive transcranial magnetic stimulation is a non-invasive neuromodulation technique used to treat different neuropsychiatric disorders, such as, depression, neuropathic pain, fibromyalgia and obsessive-compulsive disorder. It is known that the heart rate variability is altered in these conditions. Therefore the focus of this research is to show the influence of rTMS on the Heart Rate Variability.

Official TitleEffects of Repetitive Transcranial Magnetic Stimulation on Heart Rate Variability
NCT03739489
Principal SponsorUniversity of Sao Paulo
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 35 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
Agreed participate the protocol
Signing the consent form
Do not present any cardiac problems or disease
5 exclusion criteria prevent from participating
Trauma of Skull, epilepsy don't treated,
Use of medications decrease the seizure threshold
Patients in use of drugs, how cocaine and alcohol
Neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure)
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the left pre frontal dorsolateral cortex.

Group II

Active Comparator
Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the right primary motor cortex.

Group III

Active Comparator
Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the posterior superior insula right.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP)

São Paulo, BrazilOpen Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP) in Google Maps
SuspendedOne Study Center