ANOSTOOLStudy of the Microbiological Profile of Stool in Patients With Anorexia Nervosa
Data Collection
Collected from today forward - ProspectiveAnorexia Nervosa+3
+ Feeding and Eating Disorders
+ Mental Disorders
Other
Utilizing specific methods not covered by standard models in order to address unique research questions.Summary
Study start date: May 15, 2019
Actual date on which the first participant was enrolled.Anorexia nervosa is an eating disorder whose symptomatology induces a modification of the intestinal microbiota. To date, studies have shown variable profiles without linking them to metabolic and neuropsychological energy phenotyping. This intestinal dysbiosis could be involved in the maintenance of the disorders. Bidirectional communication channels exist between the microbiota, the intestine and the brain. Anomalies in these pathways could explain the impact of the microbiota on the pathophysiology of anorexia nervosa. Therapeutic interventions would then be possible to restore the microbiota in anorexia nervosa and influence the treatment of this disease. This study aims to explore the hypothesis of disruption of the microbiota-intestinal-brain axis transversely and measuring the intestinal microbiota, urinary metabolome, biological factors nutritional, immunological and physiological plasma plasma of the intestine, and finally, the psychological dimensions characteristic of anorexia nervosa.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Other
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Female
Biological sex of participants that are eligible to enroll.From 18 to 30 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion criteria common to all four groups * Patient affiliated or entitled to a social security scheme * Patient who received informed information about the study * Patient does not object to participating in the study Inclusion criteria specific to mental anorexia * BMI between 13 and 17.5 kg/m2 * Diagnostic and Statistical Manual of Mental Disorders IV restrictive anorexia nervosa diagnostic criteria * Evolution of the troubles since less than 1 year. * with feeling of hunger: "hunger" = total score on the 24-hour hunger scale \> 15 and presence of the three prandial peaks (score = 3) * having lost the feeling of hunger: "not hungry" = total score on the 24-hour hunger scale ≤ 5 and absence of the three prandial peaks (score ≤ 2) Inclusion criteria specific to constitutionally thin patients * BMI between 13 and 17.5 kg/m2 * Stable weight for at least 3 months * No eating disorder * No markers of undernutrition Inclusion criteria specific to normal weight subjects * 20 kg/m2 ≤ BMI ≤ 25 kg/m2 * Stable weight for at least 3 months * No eating disorder * No markers of undernutrition Non-inclusion criteria for all subjects : * Antibiotic treatment during the 2 months preceding the sampling. * History of immune system/autoimmune disease: Immune deficiency, Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, psoriasis, Behçet's disease, celiac disease, type I diabetes. * History of metabolic pathology: intestinal malabsorptive disease * Medical or surgical history deemed by the investigator to be incompatible with this study. * Severe progressive condition other * Pregnant woman * Majors under guardianship or subjects deprived of their liberty by judicial or administrative decision * Ongoing psychotropic treatment * Progressive diarrhea (Bristol Type V and VI)
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location