Suspended

A Pilot Study of Digital Cognitive Behavioral Therapy for Veterans With Insomnia and Comorbid Psychopathology

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What is being tested

Cognitive Behavioral Therapy for Insomnia (CBT-i)

Behavioral
Who is being recruted

Trauma and Stressor Related Disorders+7

+ Anxiety Disorders

+ Mental Disorders

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: February 2018
See protocol details

Summary

Principal SponsorPalo Alto Veterans Institute for Research
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 5, 2018

Actual date on which the first participant was enrolled.

Cognitive Behavioral Therapy for Insomnia (CBT-I) is considered the front-line intervention for individuals with insomnia and has recently been rolled-out throughout the Veterans Health Administration (VHA; Manber et al., 2012). CBT-I includes behavioral (sleep restriction, stimulus control, relaxation exercises), cognitive (cognitive restructuring, mindfulness exercise), and psychoeducation (sleep hygiene) components. While CBT-I has been demonstrated to be a highly efficacious and effective intervention, it is a specialized intervention that can be costly and is in limited supply based on the level of training required and number of providers available. For this reason, digital administration of CBT-I has been examined and research has demonstrated initial efficacy among community samples (Ritterband et al., 2009; Vincent et al., 2009; Espie et al., 2012), with one platform, Sleepio, demonstrating efficacy compared to a placebo intervention (Espie et al., 2012; Espie et al., 2014). For this reason, the current study will utilize the Sleepio platform which provides an interactive, customized and tailored delivery of CBT-I.

Official TitleA Pilot Study of Digital Cognitive Behavioral Therapy for Veterans With Insomnia and Comorbid Psychopathology
NCT03688763
Principal SponsorPalo Alto Veterans Institute for Research
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

5 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Trauma and Stressor Related DisordersAnxiety DisordersMental DisordersSleep Initiation and Maintenance DisordersNervous System DiseasesSleep Wake DisordersStress Disorders, Post-TraumaticSleep Disorders, IntrinsicDyssomniasStress Disorders, Traumatic

Criteria

Inclusion Criteria: Participants must be: * at least 18 years of age (no upper age limit) * meet DSM-5 defined criteria for insomnia disorder * be on a stable dose of any prescription medication (including sleep medication) for at least 2 weeks prior to the in-person screening assessment * have comorbid psychopathology (i.e., symptoms of Posttraumatic Stress Disorder (PTSD), anxiety, and/or depression) Exclusion Criteria: * limited mental competency (not oriented to person, place, or time) and the inability to give informed, voluntary, or written consent to participate * high risk for sleep apnea (STOP-Bang score \>/= 3) * current or previous diagnosis of sleep apnea that is untreated * history of moderate or severe Traumatic Brain Injury * current substance or alcohol use disorder, moderate to severe, in the past 3 months * current bipolar disorder * current or lifetime psychotic disorders * seizure disorders * moderate to high risk of suicide in the past month

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Participants will receive 6 sessions of digitally administered CBTi using the Sleepio platform over the course of 12 weeks. Each session lasts on average 30-60 minutes, and is tailored to participant's progress and problems. During the treatment phase, between sessions, participants complete the Consensus Sleep Diary to track their progress.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

VA Palo Alto Health Care System

Palo Alto, United StatesOpen VA Palo Alto Health Care System in Google Maps
SuspendedOne Study Center
A Pilot Study of Digital Cognitive Behavioral Therapy for Veterans With Insomnia and Comorbid Psychopathology | PatLynk