TODOSDoxycycline vs Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections in Areas with High CA-MRSA Prevalence

This study focuses on understanding the best treatment for uncomplicated skin and soft tissue infections, like abscesses and cellulitis, particularly in areas with a high presence of a resistant bacteria known as CA-MRSA. The trial involves both children and adults from Los Angeles and St. Louis. These locations have a high number of cases caused by CA-MRSA, which makes it crucial to find effective treatments. The study compares two antibiotics, Doxycycline (DOXY) and Trimethoprim-Sulfamethoxazole (TMP-SMX), which are not well-studied for these infections but are frequently used. The goal is to see which medication is more effective in curing infections and has fewer side effects, thereby helping doctors choose the best option for treating patients with these common skin infections. Participants in this trial will be randomly assigned to receive either Doxycycline or TMP-SMX, in a setting that ensures neither they nor the doctors know which treatment is given, to maintain objectivity. The study measures success by checking if the infection is cured without any complications like fever, lesion spreading, or needing additional antibiotics or surgeries. The trial also looks at how often the infection comes back or doesn't respond to treatment, especially in those who have Staphylococcus aureus bacteria in their nose or throat. This research will help determine the safest and most effective treatment options for dealing with these challenging skin infections.