GT-PTThrombin Generation and Deep Vein Thrombosis Risk After Lower Limb Orthopedic Surgery

This clinical trial focuses on understanding the risk of developing deep vein thrombosis (DVT), a condition where blood clots form in the deep veins of the body, usually in the legs. This study is specifically for individuals who have undergone prosthetic orthopedic surgery of the lower limbs, such as total hip or knee replacement. The study aims to predict the risk of early DVT after surgery by comparing the results of two thrombin generation tests performed before the surgery. Thrombin is a key protein involved in blood clotting. The hope is that the findings of this study could help improve care for patients undergoing such surgeries by providing a way to predict and potentially prevent DVT. In this study, participants will undergo two thrombin generation tests before their surgery. One test will be performed without soluble thrombomodulin, a protein that helps regulate blood clotting, and the other test will be performed with it. The ratio between the values of these two tests will be calculated. After surgery, participants will be monitored for symptoms of DVT in the legs, elsewhere in the body, and for symptoms of pulmonary embolism, a condition where a blood clot travels to the lungs. The study measures the occurrence of these conditions as 'yes' or 'no' and also records the numerical value of the test ratio. The potential benefit of participating in this study is gaining a better understanding of one's risk of DVT after surgery.