Suspended

Arterial Dynamic Elastance in ICU Patients on Inotropic or Vasopressor Drugs

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Study Aim

The study aims to assess changes in dynamic arterial elastance in ICU patients receiving inotropic or vasopressor drugs as displayed on a hemodynamic monitor.

What is being tested

dobutamine

+ norepinephrine

Diagnostic Test
Who is being recruted

Infections+3

+ Inflammation

+ Pathologic Processes

From 18 to 75 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Diagnostic Study

Interventional
Study Start: March 2019
See protocol details

Summary

Principal SponsorUniversitair Ziekenhuis Brussel
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 31, 2019

Actual date on which the first participant was enrolled.

This study focuses on assessing the cardiovascular health and blood flow dynamics in patients who are in Intensive Care Units (ICU) and depend on drugs that support heart function or blood pressure. These drugs, known as inotropes and vasopressors, help the heart pump more effectively or raise blood pressure. The aim is to understand how these patients' hearts and blood vessels respond to treatment by monitoring changes in blood flow and pressure. By doing so, the study hopes to improve patient care by optimizing how fluids and medications are administered, particularly in critical conditions where the heart and blood circulation are compromised. Participants in this study will undergo monitoring that combines blood pressure readings with tools that measure how much blood the heart pumps. This monitoring can be done using devices that might either be placed on the skin or require a small procedure to place them inside the body. The study evaluates a measurement called dynamic arterial elastance, which helps understand the relationship between changes in blood pressure and blood flow during each heartbeat. The results will be captured on a hemodynamic monitor, which provides real-time feedback to help adjust medical care. This approach aims to tailor treatment for better clinical outcomes in ICU settings.

Official TitleClinical Assessment of Arterial Dynamic Elastance in ICU Patients, Dependent on Inotropic or Vasopressor Drugs.
NCT03621618
Principal SponsorUniversitair Ziekenhuis Brussel
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Diagnostic Study

Diagnostic studies focus on improving how we detect or confirm a disease. They test new tools or techniques that could provide faster or more accurate diagnoses.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 75 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

InfectionsInflammationPathologic ProcessesPathological Conditions, Signs and SymptomsSystemic Inflammatory Response SyndromeSepsis

Criteria

1 inclusion criteria required to participate
ICU patients, treated/supported with noradrenalin or dobutamine.

10 exclusion criteria prevent from participating
Septic shock

Aortic valve regurgitation and defect of septum

Severe aortic sclerosis, aortic prosthesis

Severe hypertension (MAP \> 130 mmHg)

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Cardiac failure

Group II

Sepsis

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

universitair Ziekenhuis Brussel

Jette, BelgiumOpen universitair Ziekenhuis Brussel in Google Maps
SuspendedOne Study Center