Completed
The Efficacy and Safety of Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchymal Stem Cells in Infertile Women With Thin Endometrium or Endometrial Scarring
What is being tested
UC-MSCs therapy
Procedure
Who is being recruted
Urogenital Diseases+4
+ Genital Diseases
+ Female Urogenital Diseases and Pregnancy Complications
From 20 to 42 Years
+13 Eligibility Criteria
How is the trial designed
Treatment Study
Interventional
Study Start: September 2018
Summary
Principal SponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner
Study start date: September 10, 2018
Actual date on which the first participant was enrolled.The purpose of the study is to evaluate the safety and effectiveness of the collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (UC-MSCs) in infetile women with thin endometrium or endometrial scarring.
Official TitleThe Efficacy and Safety of Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchymal Stem Cells in Infertile Women With Thin Endometrium or Endometrial Scarring
Principal SponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
20 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Female
Biological sex of participants that are eligible to enroll.From 20 to 42 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Urogenital DiseasesGenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsGenital Diseases, FemaleInfertilityInfertility, FemaleFemale Urogenital Diseases
Criteria
5 inclusion criteria required to participate
Infertile patients with clear fertility desires
Diagnosed with thin endometrium or endometrial scarring for whom drugs and surgical interventions were ineffective
20-42 years old
Normal ovarian function or with frozen embryos
Show More Criteria
8 exclusion criteria prevent from participating
With abnormal chromosome karyotype
With other uterine diseases including large intramural myomas, severe endometriosis, severe adenomyosis, severe congenital uterine malformations, endometrial tuberculosis, vaginitis and endometritis
Systemic diseases: hypertension, diabetes, and so on
Contraindications to pregnancy
Show More Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Treatment Groups
Study Objectives
One single intervention group is designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Experimentaltransplant collagen scaffold loaded with UC-MSCs to treat infertility caused by thin endometrium or endometrial scarring
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Suspended
CompletedOne Study Center